Організаційні та нормативно-правові заходи підготовки системи паліативної та хоспісної допомоги України до широкого використання медичного канабісу
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Ключові слова

хронічний біль
наркотичні знеболювальні
марихуана
ПТСР
аноресія

Як цитувати

Нестеренко, В. (2024). Організаційні та нормативно-правові заходи підготовки системи паліативної та хоспісної допомоги України до широкого використання медичного канабісу. Медицина сьогодні і завтра, 93(1), 56-74. https://doi.org/10.35339/msz.2024.93.1.nes

Анотація

В Україні завершується процедура легалізації медичного канабісу, необхідного приблизно для 6 млн пацієнтів з онкозахворюваннями паліативних стадій, розсіяним склерозом, епілепсією, боковим амніоторофічним склерозом, фіброміалгією, артритом, ВІЛ/СНІДом, глаукомою, посттравматичним стресовим розладом, хворобами Альцгеймера, Паркінсона, синдромами Туретта, Леннокса-Госте, Драве, подразненого кишківника, болем у спині, хронічними болем внаслідок травм спинного мозку, діабетичної нейропатії, постгерпетичної невралгії. Канабіс необхідний таким хворим для подолання спастичності, хронічного болю, нудоти, блювання, анорексії, депресії, підвищеного очного тиску. Він може бути доповненням лікування іншими фармпрепаратами або їх альтернативою. Напередодні набуття чинності відповідного закону необхідно визначити основні напрямки швидкого напрацювання необхідних підзаконних актів (клінічних протоколів, інструкцій тощо) для швидкого початку широкого використання канабісу у клінічній практиці, зокрема у паліативній медицині. Методами системного аналізу та бібліосемантичним проведене дослідження наукових літературних джерел у Google Scholar та PubMed для вивчення головних властивостей медичного канабісу, медико-соціальних ризиків його використання, зокрема побічних дій, збільшення нелегального рекреаційного вживання трав’яного канабісу. Вивчений досвід інших країн, в яких медичний канабіс вже легалізований (США, Канада, Австралія, Данія, Німеччина, Ізраїль, Швейцарія). Визначений перелік нормативно-правових актів України, що можуть регулювати використання медичного канабісу: 27 клінічних настанов, заснованих на доказах; 27 стандартів та протоколів медичної допомоги. Визначені можливі сценарії та запропоновані необхідні заходи щодо прийняття нормативно-правових актів для остаточної декриміналізації канабісу, визначення та прогнозування потреби у канабісі.

Ключові слова: хронічний біль, наркотичні знеболювальні, марихуана, ПТСР, аноресія.

Архівовано: https://doi.org/10.5281/zenodo.12699421

https://doi.org/10.35339/msz.2024.93.1.nes
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Посилання

Holovanova IA, Shevchenko AS. Determination of the main needs of palliative patients and ways of their provision in the healthcare system of Ukraine. Experimental and Clinical Medicine. 2021;90(3):88-94. DOI: 10.35339/ekm.2021.90.3.hos.

Lekhan VM. Retrospective analysis of the construction of the national system of hospice and palliative care in Great Britain. Inter Collegas. 2024;11(1):5p. In press. DOI: 10.35339/ic.11.1.lvm.

Nesterenko VG. On the procedure for providing palliative and hospice care in Ukraine. Medicine Today and Tomorrow. 2021;90(2):57-62. DOI: 10.35339/msz.2021.90.2.nes. [In Ukrainian].

Wallace MS, Marcotte TD, Umlauf A, Gouaux B, Atkinson JH. Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy. J Pain. 2015;16(7):616-27. DOI: 10.1016/j.jpain.2015.03.008. PMID: 25843054.

Lynch ME, Ware MA. Cannabinoids for the Treatment of Chronic Non-Cancer Pain: An Updated Systematic Review of Randomized Controlled Trials. J Neuroimmune Pharmacol. 2015;10(2):293-301. DOI: 10.1007/s11481-015-9600-6. PMID: 25796592.

Forsythe ML, Boileau AJ. Use of cannabinoids for the treatment of patients with post-traumatic stress disorder. J Basic Clin Physiol Pharmacol. 2021;33(2):121-32. DOI: 10.1515/jbcpp-2020-0279. PMID: 33662194.

Nacasch N, Avni C, Toren P. Medical cannabis for treatment-resistant combat PTSD. Front Psychiatry. 2023;13:1014630. DOI: 10.3389/fpsyt.2022.1014630. PMID: 36741572.

Devinsky O, Cilio MR, Cross H, Fernandez-Ruiz J, French J, Hill C, et al. Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia. 2014;55(6):791-802. DOI: 10.1111/epi.12631. PMID: 24854329.

Treves N, Mor N, Allegaert K, Bassalov H, Berkovitch M, Stolar OE, Matok I. Efficacy and safety of medical cannabinoids in children: a systematic review and meta-analysis. Sci Rep. 2021;11(1):23462. DOI: 10.1038/s41598-021-02770-6. PMID: 34873203.

Devinsky O, Cross JH, Laux L, Marsh E, Miller I, Nabbout R, et al.; Cannabidiol in Dravet Syndrome Study Group. Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome. N Engl J Med. 2017;376(21):2011-20. DOI: 10.1056/NEJMoa1611618. PMID: 28538134.

Koppel BS, Brust JC, Fife T, Bronstein J, Youssof S, Gronseth G, Gloss D. Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2014;82(17):1556-63. DOI: 10.1212/WNL.0000000000000363. PMID: 24778283.

Ball S, Vickery J, Hobart J, Wright D, Green C, Shearer J, et al. The Cannabinoid Use in Progressive Inflammatory brain Disease (CUPID) trial: a randomised double-blind placebo-controlled parallel-group multicentre trial and economic evaluation of cannabinoids to slow progression in multiple sclerosis. Health Technol Assess. 2015;19(12):1-187. DOI: 10.3310/hta19120. PMID: 25676540.

Timpone JG, Wright DJ, Li N, Egorin MJ, Enama ME, Mayers J, Galetto G. The safety and pharmacokinetics of single-agent and combination therapy with megestrol acetate and dronabinol for the treatment of HIV wasting syndrome. The DATRI 004 Study Group. Division of AIDS Treatment Research Initiative. AIDS Res Hum Retroviruses. 1997;13(4):305-15. DOI: 10.1089/aid.1997.13.305. PMID: 9071430.

Sachs J, McGlade E, Yurgelun-Todd D. Safety and Toxicology of Cannabinoids. Neurotherapeutics. 2015;12(4):735-46. DOI: 10.1007/s13311-015-0380-8. PMID: 26269228.

Bilkei-Gorzo A, Albayram O, Draffehn A, Michel K, Piyanova A, Oppenheimer H, et al. A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice. Nat Med. 2017;23(6):782-7. DOI: 10.1038/nm.4311. PMID: 28481360.

Abate G, Uberti D, Tambaro S. Potential and Limits of Cannabinoids in Alzheimer's Disease Therapy. Biology (Basel). 2021;10(6):542. DOI: 10.3390/biology10060542. PMID: 34204237.

Cohen K, Weizman A, Weinstein A. Positive and Negative Effects of Cannabis and Cannabinoids on Health. Clin Pharmacol Ther. 2019;105(5):1139-47. DOI: 10.1002/cpt.1381. PMID: 30703255.

Lekhan VM. The importance of medical cannabis for solving the problem of providing analgesia to palliative patients in Ukraine. Experimental and Clinical Medicine. 2024;93(1):6p. DOI: 10.35339/ekm.2024.93.1.lvm.

History. Cannabis in the USSR. Konoplyana Pravda, 23 Jan 2018 [Internet]. Available at: https://konopravda.com/2018/01/23/istoriya-kanabis-u-srsr-2/ [accessed 20 Mar 2024].

Crocq MA. History of cannabis and the endocannabinoid system. Dialogues Clin Neurosci. 2020;22(3):223-8. DOI: 10.31887/DCNS.2020.22.3/mcrocq. PMID: 33162765.

Johnson JK, Colby A. History of Cannabis Regulation and Medicinal Therapeutics: It's Complicated. Clin Ther. 2023;45(6):521-6. DOI: 10.1016/j.clinthera.2023.04.011. PMID: 37414502.

Charitos IA, Gagliano-Candela R, Santacroce L, Bottalico L. The Cannabis Spread throughout the Continents and its Therapeutic Use in History. Endocr Metab Immune Disord Drug Targets. 2021;21(3):407-17. DOI: 10.2174/1871530320666200520095900. PMID: 32433013.

Baratta F, Pignata I, Ravetto Enri L, Brusa P. Cannabis for Medical Use: Analysis of Recent Clinical Trials in View of Current Legislation. Front Pharmacol. 2022;13:888903. DOI: 10.3389/fphar.2022.888903. PMID: 35694246.

Single Convention on Narcotic Drugs, 1961. International Narcotics Control Board [Internet]. Available at: https://www.incb.org/incb/en/narcotic-drugs/1961_Convention.html [accessed 20 Mar 2024].

Single Convention on Narcotic Drugs, 1961. United Nations Office on Drugs and Crime [Internet]. Available at: https://www.unodc.org/unodc/en/treaties/single-convention.html [accessed 20 Mar 2024].

United Nations Office on Drugs and Crime. World Drug Report 2023. Executive summary. Vienna: UNODC; 2023. 36 р. Available at: https://www.unodc.org/res/WDR-2023/WDR23_Exsum_fin_DP.pdf

Draft Law on Regulation of the Circulation of Cannabis Plants for Medical, Industrial Purposes, Scientific and Scientific-Technical Activities to Create Conditions for Expanding Patients' Access to Necessary Treatment of Oncological Diseases and Post-Traumatic Stress Disorders Acquired as a Result of War. Verkhovna Rada (Parliament) of Ukraine. Bills. Available at: https://itd.rada.gov.ua/billInfo/Bills/Card/39783 [Accessed 20 Mar 2024]. [In Ukrainian].

United Nations Office on Drugs and Crime. World Drug Report, 2015. Vienna: UNODC; 2015. 162 p. Available at: https://www.unodc.org/documents/wdr2015/World_Drug_Report_2015.pdf

United Nations Office on Drugs and Crime. World Drug Report 2023. Executive summary. Vienna: UNODC; 2023. 36 р. Available at: https://www.unodc.org/res/WDR-2023/WDR23_Exsum_fin_DP.pdf

Grinspoon P. Medical marijuana. Harvard Health Blog, 10 Apr 2020 [Internet]. Available at: https://www.health.harvard.edu/blog/medical-marijuana-2018011513085 [accessed 20 Mar 2024].

Weinberger D, Gandilhon M, Shah J, Lalam N. Illegal cannabis cultivation in Europe: new developments. EchoGéo. 2019;48. DOI: 10.4000/echogeo.17704.

Cannabis Cultivation Market Size, Share & Trends Analysis Report By Biomass (Hemp, Marijuana), By Application, By Region, And Segment Forecasts, 2023–2030. USA: Grand View Research, Inc.; 2022. Available at: https://www.grandviewresearch.com/industry-analysis/cannabis-cultivation-market

Petrushko L. Zelensky called on the Verkhovna Rada to legalize medical cannabis in Ukraine. How can a business make money on this market (and why millions of Ukrainians need it). Forbes Ukraine, 28 Jun 2023 [Internet]. Available at: http://surl.li/gjqubv [accessed 20 Mar 2024].

Ukraine (104/180). Corruption Perceptions Index. Transparency International, 2023. Available at: https://www.transparency.org/en/cpi/2023

Sayenko Kharenko. Assessment of business security in Ukraine. Survey among managers and owners of medium and large businesses, June–September 2021. UK: PwC; 2022. 48 p. Available at: https://www.pwc.com/ua/en/survey/2022/assessment-of-business-security-in-Ukraine.pdf [in Ukrainian].

Guideline of the Ministry of Health of Ukraine (MH) of Ukraine СТ-Н MHU 42-4.0:2020, based on the " The Rules Governing Medicinal Products in the European Union. Volume 4. EU Guidelines to Good Manufacturing Practice Medicinal Products for Human and Veterinary Use, MOD", approved by the Order of the Ministry of Health of Ukraine No.95 on 16 Feb 2009 "On the approval of documents on quality assurance of medicinal products" (as amended by the Order of the Ministry of Health of Ukraine No.1023 on 04 May 2020). Legislation of Ukraine, Verkhovna Rada (Parliament) of Ukraine, valid on 20 Mar 2024. Available at: https://zakon.rada.gov.ua/rada/show/v0095282-09#n4777 [in Ukrainian].

United Nations Office on Drugs and Crime. World Drug Report 2023. Executive summary. Vienna: UNODC; 2023. 36 р. Available at: https://www.unodc.org/res/WDR-2023/WDR23_Exsum_fin_DP.pdf

Dugas EN, Sylvestre MP, Ewusi-Boisvert E, Chaiton M, Montreuil A, O'Loughlin J. Early Risk Factors for Daily Cannabis Use in Young Adults. Can J Psychiatry. 2019;64(5):329-37. DOI: 10.1177/0706743718804541. PMID: 30373372.

Hill S, Shanahan L, Costello EJ, Copeland W. Predicting Persistent, Limited, and Delayed Problematic Cannabis Use in Early Adulthood: Findings From a Longitudinal Study. J Am Acad Child Adolesc Psychiatry. 2017;56(11):966-74.e4. DOI: 10.1016/j.jaac.2017.08.012. PMID: 29096779.

Jones EL, Rozenman M. Social Evaluation in Emerging Adults: Associations with Interpretation Bias and Perceived Social Support. Child Psychiatry Hum Dev. 2024 Feb 8. DOI: 10.1007/s10578-023-01663-1. PMID: 38329648.

Shevchenko AS, Shtefan LV, Shumskyi OL, Kucherenko SM, Kucherenko NS, Brown GW. Valeological competence of non-medical students as a tool for their healthy and safe future life. Inter Collegas. 2024;11(2):8p. In press. DOI: 10.35339/ic.11.2.sss.

Shevchenko AS, Shevchenko VV, Brown GW. The preventive direction of modern theories of health and health-saving in public health and education. Inter Collegas. 2024;11(1):7p. In press. DOI: 10.35339/ic.11.1.ssb.

Dronabinol (Tetrahydrocannabinol). PubChem, No.16078. National Center for Biotechnology Information. National (USA) Library of Medicine [Internet]. Available at: https://pubchem.ncbi.nlm.nih.gov/compound/16078 [accessed 20 Mar 2024].

Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344-64. DOI: 10.1111/j.1476-5381.2011.01238.x. PMID: 21749363.

Lu HC, Mackie K. Review of the Endocannabinoid System. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021;6(6):607-15. DOI: 10.1016/j.bpsc.2020.07.016. PMID: 32980261.

Pandey R, Mousawy K, Nagarkatti M, Nagarkatti P. Endocannabinoids and immune regulation. Pharmacol Res. 2009;60(2):85-92. DOI: 10.1016/j.phrs.2009.03.019. PMID: 19428268.

Klein C, Hill MN, Chang SC, Hillard CJ, Gorzalka BB. Circulating endocannabinoid concentrations and sexual arousal in women. J Sex Med. 2012;9(6):1588-601. DOI: 10.1111/j.1743-6109.2012.02708.x. PMID: 22462722.

Donvito G, Nass SR, Wilkerson JL, Curry ZA, Schurman LD, Kinsey SG, Lichtman AH. The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain. Neuropsychopharmacology. 2018;43(1):52-79. doi: 10.1038/npp.2017.204. Epub 2017 Aug 31. PMID: 28857069; PMCID: PMC5719110.

de Melo Reis RA, Isaac AR, Freitas HR, de Almeida MM, Schuck PF, Ferreira GC, et al. Quality of Life and a Surveillant Endocannabinoid System. Front Neurosci. 2021;15:747229. DOI: 10.3389/fnins.2021.747229. PMID: 34776851.

Nutt DJ, King LA, Phillips LD; Independent Scientific Committee on Drugs. Drug harms in the UK: a multicriteria decision analysis. Lancet. 2010;376(9752):1558-65. DOI: 10.1016/S0140-6736(10)61462-6. PMID: 21036393.

Fitkalo OS. Prediction of the formation of alcohol dependence in persons with post-traumatic stress disorder. UMJ. 2023;6(158):84-5. DOI: 10.32471/umj.1680-3051.158.247539. [In Ukrainian].

Chorna V, Serebrennikova O, Kolomiets V, Hozak S, Yelizarova O, Rybinskyi M, et al. Posttraumatic stress disorder during full-scale war in military personnel. Young Scientist. 2023;12(124):28-39. DOI: 10.32839/2304-5809/2023-12-124-28. [In Ukrainian].

The impact of war on mental health is enormous (Victor Lyashko). Ministry of Health of Ukraine, 7 Jun 2022 [Internet]. Available at: http://surl.li/cmhhyk [accessed 20 Mar 2024]. [In Ukrainian].

Lake S, Kerr T, Buxton J, Walsh Z, Marshall BD, Wood E, Milloy MJ. Does cannabis use modify the effect of post-traumatic stress disorder on severe depression and suicidal ideation? Evidence from a population-based cross-sectional study of Canadians. J Psychopharmacol. 2020;34(2):181-8. DOI: 10.1177/0269881119882806. PMID: 31684805.

Orhurhu V, Urits I, Olusunmade M, Olayinka A, Salisu Orhurhu M, Uwandu C, et al. Cannabis Use in Hospitalized Patients with Chronic Pain. Adv Ther. 2020;37(8):3571-83. DOI: 10.1007/s12325-020-01416-9. PMID: 32632850.

Mehmedic Z, Chandra S, Slade D, Denham H, Foster S, Patel AS, et al. Potency trends of Δ9-THC and other cannabinoids in confiscated cannabis preparations from 1993 to 2008. J Forensic Sci. 2010;55(5):1209-17. DOI: 10.1111/j.1556-4029.2010.01441.x. PMID: 20487147.

Di Forti M, Morgan C, Dazzan P, Pariante C, Mondelli V, Marques TR, et al. High-potency cannabis and the risk of psychosis. Br J Psychiatry. 2009;195(6):488-91. DOI: 10.1192/bjp.bp.109.064220. PMID: 19949195.

Therapeutic Goods Administration. Australian Government. Department of Health and Aged Care [Internet]. Available at: https://www.tga.gov.au

Knight G, Hansen S, Connor M, Poulsen H, McGovern C, Stacey J. The results of an experimental indoor hydroponic Cannabis growing study, using the 'Screen of Green' (ScrOG) method-Yield, tetrahydrocannabinol (THC) and DNA analysis. Forensic Sci Int. 2010;202(1-3):36-44. DOI: 10.1016/j.forsciint.2010.04.022. PMID: 20462712.

General Medical Council. Available at: https://www.gmc-uk.org

Davies DS. Cannabis scheduling review part 1: the therapeutic and medicinal benefits of cannabis-based products. UK Government. Department of Health and Social Care. 2018. 18 p. Available at: https://www.gov.uk/government/publications/cannabis-scheduling-review-part-1

Information for doctors on Cannabis-based products for medicinal use (CBPMs). General Medical Council [Internet]. Available at: https://www.gmc-uk.org/professional-standards/learning-materials/information-for-doctors-on-cannabis-based-products-for-medicinal-use [accessed 20 Mar 2024].

Danish Medicines Agency. Danish Ministry of Interior and Health. Available at: https://laegemiddelstyrelsen.dk/en

Isralowitz R, Reznik A, Zolotov Y, Grinstein-Cohen O, Wacht O, Pruginin I, et al. Toward medical cannabis education in Israel. Complement Ther Med. 2021;58:102709. DOI: 10.1016/j.ctim.2021.102709. PMID: 33716092.

Zarhin D. The trajectory of "medical cannabis" in Israel: Driving medicalization in different directions. Int J Drug Policy. 2020;82:102809. DOI: 10.1016/j.drugpo.2020.102809. PMID: 32516686.

Cannabinoid Laws in Germany. GVB Biopharma, 2023. Available at: https://www.gvbbiopharma.com/cannabinoid-laws-in-germany

Federal Office of Public Health FOPH. Swiss government. Available at: https://www.bag.admin.ch/bag/en/home.html

Baltes-Flueckiger L, Steinauer R, Meyer M, Vogel M, Walter M. Effects of cannabis regulation in Switzerland: Study protocol of a randomized controlled trial. Front Psychiatry. 2023;14:1139325. DOI: 10.3389/fpsyt.2023.1139325. PMID: 37032954.

Kilcher G, Zwahlen M, Ritter C, Fenner L, Egger M. Medical use of cannabis in Switzerland: analysis of approved exceptional licences. Swiss Med Wkly. 2017;147:w14463. DOI: 10.4414/smw.2017.14463. PMID: 28695562.

Cannabinoid Laws in Switzerland. GVB Biopharma, 2023. Available at: https://www.gvbbiopharma.com/cannabinoid-laws-in-switzerland/

Willi C. Cannabis law and legislation in Switzerland. CMS [Internet]. Available at: https://cms.law/en/int/expert-guides/cms-expert-guide-to-a-legal-roadmap-to-cannabis/switzerland [accessed 20 Mar 2024].

Nesterenko VG. The need for palliative and hospice care in Ukraine in 2018–2020. Medicine Today and Tomorrow. 2021;90(3):43-52. DOI: 10.35339/msz.2021.90.3.nes. [In Ukrainian].

Holovanova IA, Shevchenko AS. The issue of patient-oriented organization of palliative and hospice care in Ukraine. Experimental and Clinical Medicine. 2021;90(2):21-7. DOI: 10.35339/ekm.2021.90.2.hos.

Holovanova IA, Shevchenko AS. Evaluation of packaged funding programs for palliative and hospice care by the National Health Service of Ukraine. Experimental and Clinical Medicine. 2021;90(4):45-52. DOI: 10.35339/ekm.2021.90.4.hos.

Chronic pain syndrome in adults and children, 6 Apr 2023. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/hronichnyj-bolovyj-syndrom/ [accessed 20 Mar 2024]. [In Ukrainian].

HIV infection, 15 Aug 2023. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/vil-infekcziya [accessed 20 Mar 2024]. [In Ukrainian].

Glaucoma, 26 May 2023. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/glaukoma [accessed 20 Mar 2024]. [In Ukrainian].

Dementia, 29 Nov 2019. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/demencziya [accessed 20 Mar 2024]. [In Ukrainian].

Depression, 29 Nov 2019. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/depresiya [accessed 20 Mar 2024]. [In Ukrainian].

Inflammatory bowel diseases, 06 Oct 2023. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/zapalni-zahvoryuvannya-kyshechnyka [accessed 20 Mar 2024]. [In Ukrainian].

Malignant neoplasms of the head and neck, 20 Oct 2023. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/rak-gortani [accessed 20 Mar 2024]. [In Ukrainian].

Malignant neoplasms of the uterine body, 02 Oct 2023. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/zloyakisni-novoutvorennya-tila-matky [accessed 20 Mar 2024]. [In Ukrainian].

Colorectal cancer, 29 Nov 2019. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/kolorektalnyj-rak [accessed 20 Mar 2024]. [In Ukrainian].

Melanoma, 09 Jun 2023. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/melanoma [accessed 20 Mar 2024]. [In Ukrainian].

Multiple myeloma, 29 Nov 2019. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/mnozhynna-miyeloma [accessed 20 Mar 2024]. [In Ukrainian].

Osteosarcoma, 23 Jun 2022. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/osteosarkoma [accessed 20 Mar 2024]. [In Ukrainian].

Primary retroperitoneal sarcomas, 04 Jun 2024. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/pervynni-zaocherevynni-sarkomy [accessed 20 Mar 2024]. [In Ukrainian].

Post-traumatic stress disorder, 29 Nov 2019. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/posttravmatychnyj-stresovyj-rozlad [accessed 20 Mar 2024]. [In Ukrainian].

Mental and behavioral disorders (addiction syndrome) due to the use of opioids, 10 Nov 2020. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/psyhichni-ta-povedinkovi-rozlady-syndrom-zalezhnosti-vnaslidok-vzhyvannya-opioyidyiv [accessed 20 Mar 2024]. [In Ukrainian].

Lung cancer, 29 Nov 2019. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/rak-legeni [accessed 20 Mar 2024]. [In Ukrainian].

Mammary gland cancer, 29 Nov 2019. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/rak-molochnoyi-zalozy [accessed 20 Mar 2024]. [In Ukrainian].

Kidney cancer, 23 Jun 2022. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/rak-nyrky [accessed 20 Mar 2024]. [In Ukrainian].

Prostate cancer, 22 Jun 2023. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/rak-peredmihurovoyi-zalozy [accessed 20 Mar 2024]. [In Ukrainian].

Stomach cancer, 05 Dec 2023. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/rak-shlunka [accessed 20 Mar 2024]. [In Ukrainian].

Rheumatoid arthritis, 29 Nov 2019. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/revmatoyidnyj-artryt [accessed 20 Mar 2024]. [In Ukrainian].

Multiple sclerosis in adults, 04 Jul 2024. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/rozsiyanyj-skleroz-u-doroslyh-2 [accessed 20 Mar 2024]. [In Ukrainian].

Ewing sarcoma, 22 Jun 2023. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/sarkoma-yuyinga [accessed 20 Mar 2024]. [In Ukrainian].

Sarcomas of soft tissues of the limbs and trunk, 10 Aug 2023. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/sarkomy-myakyh-tkanyn-kinczivok-ta-tuluba [accessed 20 Mar 2024]. [In Ukrainian].

Chronic obstructive pulmonary disease, 29 Nov 2019. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/hronichne-obstruktyvne-zahvoryuvannya-legeni [accessed 20 Mar 2024]. [In Ukrainian].

Chronic lymphoid leukemia, 09 Sep 2022. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/hronichnyj-limfoyidnyj-lejkoz [accessed 20 Mar 2024]. [In Ukrainian].

Chronic myeloid leukemia, 29 Nov 2019. State Expert Center of the Ministry of Health of Ukraine [Internet]. Available at: https://www.dec.gov.ua/mtd/hronichnyj-miyeloyidnyj-lejkoz [accessed 20 Mar 2024]. [In Ukrainian].

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