Keywords
herpesviruses
immune complexes
Gammalin
Nimesil
How to Cite
Abstract
The quantitative and qualitative composition of circulating immune complexes (CIC) in the lacrimal fluid and blood serum of patients with herpesvirus keratoconjunctivitis (ИКС) caused by herpes simplex virus type 1 (HSV-1) were studied. The effectiveness of the treatment by gammalin and nimesil was evaluated. 65 patients with ИКС from 24 to 54 years of age of both sexes were examined. Polymerase chain reaction for HSV-1 was positive in all patients. The control group consisted of 32 patients who received basic treatment with Zovirax ointment and Interferon. The main group consisted of 33 patients who received Gammalin and Nimesil in addition to basic therapy. The reference norm group consisted of 38 healthy donors. Tear fluid and venous blood serum were examined. The CIC was studied by precipitation in polyethylene glycol. Statistical processing was performed using the Student and Mann-Whitney tests. It has been established that in ИКС HSV-1 etiology in the lacrimal fluid of the affected eye and in the blood serum of patients the levels of total CIC increase, mainly due to medium and small fractions, which were the largest in the lacrimal fluid. In the convalescence phase violations of the quantitative and fractional composition of the CIC in the blood serum disappeared, while in the lacrimal fluid they decreased without normalization. The use of Gammalin and Nimesil in the treatment of patients with ИКС HSV-1 etiology improves the quantitative and fractional composition of CIC, both in the lacrimal fluid of the causal eye and in the blood serum of patients, which is manifested in a decrease in the number of total CIC, mainly due to a decrease in the concentrations of medium and small fractions.
Keywords: keratoconjunctivitis, herpesviruses, immune complexes, Gammalin, Nimesil.
References
Gaidash, I.S., & Panteleev, P.G. (2016). Aktivnost perekisnoho okisleniia lipidov і antioksidantnoi sistemy v sleznoi zhidkosti і syvorotke krovi bolnykh oftalmoherpesom [Activity of lipid peroxidation and antioxidant system in the tear fluid and serum of patients with ophthalmic herpes]. Medytsyna sohodni і zavtra - Medicine Today and Tomorrow, 2-3(71-72), 68-70. Retrieved from https:// msz.knmu.edu.ua/article/view/436 [in russian].
Gaidash, I.S., & Panteleev, P.G. (2017). Tsitokinovyi profd syvorotki krovi і sleznoi zhidkosti u bolnykh oftalmoherpesom [Cytokine profile of blood serum and tear fluid in patients with ophthalmoherpes]. Medytsyna sohodni і zavtra - Medicine Today and Tomorrow, 3-4(76-77), 25-29. Retrieved from https://msz.knmu.edu.ua/article/view/374 [in russian].
Pflipsen, M., Massaquoi, M., & Wolf, S. (2016). Evaluation of the painful eye. American Tamily Physician, vol. 93, issue 12, pp. 991-998. Retrieved from https://www.aafp.org/afp/2016/0615/p991.html
Klotz, D., Baumgartner ,W., & Gerhauser, I. (2017). Type I interferons in the pathogenesis and treatment of canine diseases. Veterinary Immunology and Immunopathology, 191, 80-93. DOI: 10.1016/j.vetimm.2017.08.006. PMID: 28895871.
Chyuan, I.T., Tzeng, H.T., & Chen, J.Y. (2019). Signaling pathway softype I and type III interferons and targeted the rapies in systemic lupus erythematosus. Cells, 8(9), 963. DOI: 10.3390/cells8090963. PMID: 31450787.
Patalakha, O.V. (2016). Zminy fraktsiinoho skladu tsyrkuliuiuchykh imunnykh kompleksiv u krovi narkozalezhnykh iz heneralizovanym parodontytom ta toksychnym hepatytom [Changes in the fractional composition of circulating immune complexes in the blood of drug addicts with generalized periodontitis and toxic hepatitis]. Ukrainian Journal of Extreme Medicine named after G.O. Mozhayev, 17(3), 105-110 [in Ukrainian].
Gaidash, I.S., & Novitsky, A.N. (2017). Sostoianiie humoralnoho immuniteta u bolnykh opoiasyvaiushchim lishaiem [The state of humoral immunity inpatients with shingles . Medytsyna sohodni і zavtra - Medicine Today and Tomorrow, 3-4(76-77), 17-20. Retrieved from https://msz.knmu.edu.ua/article/view/373 [in russian].
Verbytskyi, Ye.Yu., Ovcharenko, M.O., & Loskutova, I.V. (2017). Patohenetychne znachennia imunokompleksnykh reaktsii pry posttravmatychnomu stresovomu rozladi [Pathogenetic role of immune reactions in posttraumatic stress disorders]. Arkhiv psykhiatrii - Archives of Psychiatry, 23(2(89)), 100-103. Retrieved from http://nbuv.gov.ua/UJRN/apsuh_2017_23_2_6 [in Ukrainian].
Instruktsiia dlia zastosuvannia Hamalin® (imunohlobulin proty virusu herpesu zvychainoho 1 typu liudyny) [Instructions for use Gammalin® (immunoglobulin againstherpes simplex virus type 1)]. Retrieved from https://mozdocs.kiev.ua/likiview.php?id=35939 [in Ukrainian].
Nimesil (Nimesil). Instruktsiia po primeneniiu [Nimesil. Instructions for use]. Spravochnik lekarstvennykh sredstv Vidal - Directory of medicines Vidal. Retrieved from https://www.vidal.ru/drugs/nimesil2208 [in russian].