Keywords
lipoperoxidation
antioxidant system
prostaglandins
cyclic nucleotides
diabetes mellitus
How to Cite
Abstract
Due to high prevalence of depressive disorders in general medical practice, it is not surprising that depression and somatic diseases are often comorbid conditions. Diabetes mellitus (DM) is one of the modern diseases that has a constant tendency to increase. It is known that patients with DM suffer from depression almost three times more often than patients without it. As a result of the presence of depression, the emotional state is disturbed, which quite often leads to the refusal of the patient from the prescribed adequate treatment, and eventually decompensation of DM occurs. In turn, DM causes episodes of depression, which requires the appointment of psychotropic measures and psychotherapy. But to date, there are no works on the state of metabolic homeostasis in the comorbidity of these diseases. The purpose of the study was to determine the state of metabolic homeostasis in patients with recurrent depressive disorders against the background of type 2 DM. We examined 128 patients with recurrent depressive disorder (RDD). All patients were divided into 4 groups. Patients of the first three groups had mild (group I), medium (group II) and severe (group III) degrees of severity of an ongoing RDD episode. In group IV patients, mild RDD was accompanied by type 2 DM. As a result of the study, the patients of all groups were found to have violations of the indicators of metabolic homeostasis in the form of an increase in the intensity of lipoperoxidation processes against the background of a decrease in the indicators of the enzyme link of the system of antioxidant protection, a significant increase in PGF2α and less significant PGE2, pathological changes in the indicators of cyclic nucleotides. These changes were minimal in group I, maximal in group IV, which confirms the significant influence of DM as a comorbid condition on the severity of metabolic disorders in RDD.
Keywords: recurrent depressive disorders, lipoperoxidation, antioxidant system, prostaglandins, cyclic nucleotides, diabetes mellitus.
References
Shevchuk МV, Tsiganenko OО, Taranenko OV, Kryzhevsky VV, Mankovsky BM. The practical importance of depression diagnosis in type 2 diabetes mellitus patients. International Journal of Endocrinology. 2019;1(15):50‒4. DOI: 1. Shevchuk МV, Tsiganenko OО, Taranenko OV, Kryzhevsky VV, Mankovsky BM. The practical importance of depression diagnosis in type 2 diabetes mellitus patients. International Journal of Endocrinology. 2019;1(15):50‒4. DOI: 10.22141/2224-0721.15.1.2019.158695.
Ellis P, Kitay B, Schmidt CJ. Depression in the Primary Care Setting. N Engl J Med. 2019;380(23):2278. DOI: 10.1056/NEJMc1903259. PMID: 31167069.
Foley DL, Mackinnon A, Morgan VA, Castle DJ, Waterreus A, Galletly CA. Comorbid Diabetes and Depression in a National Sample of Adults With Psychosis. Schizophr Bull. 2018;44(1):84‒92. DOI: 10.1093/schbul/sbw166. PMID: 27872261.
Park LT, Zarate CA Jr. Depression in the Primary Care Setting. N Engl J Med. 2019;380(6):559‒68. DOI: 10.1056/NEJMcp1712493. PMID: 30726688.
Stringaris A. Editorial: What is depression? J Child Psychol Psychiatry. 2017;58(12):1287‒9. DOI: 10.1111/jcpp.12844. PMID: 29148049.
Roy T, Lloyd CE. Epidemiology of depression and diabetes: a systematic review. J Affect Disord. 2012;142 Suppl:S8‒21. DOI: 10.1016/S0165-0327(12)70004-6. PMID: 23062861.
Semenkovich K, Brown ME, Svrakic DM, Lustman PJ. Depression in type 2 diabetes mellitus: prevalence, impact, and treatment. Drugs. 2015;75(6):577‒87. DOI: 10.1007/s40265-015-0347-4. PMID: 25851098.
Schmidt AM. Highlighting Diabetes Mellitus: The Epidemic Continues. Arterioscler Thromb Vasc Biol. 2018;38(1):e1‒e8. DOI: 10.1161/ATVBAHA.117.310221. PMID: 29282247.
Wormser GP, Hassett AL. Depression in the Primary Care Setting. N Engl J Med. 2019;380(23):2278‒9. DOI: 10.1056/NEJMc1903259. PMID: 31167071.
Andreev LY, Kozhemiakyn LA. Metodyka opredelenyia malonovoho dyaldehyda [Method for malonic dialdehyde determination]. Laboratornoe delo [Laboratory practice]. 1988;(11):41‒3. [In Russian].
22141/2224-0721.15.1.2019.158695.
Ellis P, Kitay B, Schmidt CJ. Depression in the Primary Care Setting. N Engl J Med. 2019;380(23):2278. DOI: 10.1056/NEJMc1903259. PMID: 31167069.
Foley DL, Mackinnon A, Morgan VA, Castle DJ, Waterreus A, Galletly CA. Comorbid Diabetes and Depression in a National Sample of Adults With Psychosis. Schizophr Bull. 2018;44(1):84‒92. DOI: 10.1093/schbul/sbw166. PMID: 27872261.
Park LT, Zarate CA Jr. Depression in the Primary Care Setting. N Engl J Med. 2019;380(6):559‒68. DOI: 10.1056/NEJMcp1712493. PMID: 30726688.
Stringaris A. Editorial: What is depression? J Child Psychol Psychiatry. 2017;58(12):1287‒9. DOI: 10.1111/jcpp.12844. PMID: 29148049.
Roy T, Lloyd CE. Epidemiology of depression and diabetes: a systematic review. J Affect Disord. 2012;142 Suppl:S8‒21. DOI: 10.1016/S0165-0327(12)70004-6. PMID: 23062861.
Semenkovich K, Brown ME, Svrakic DM, Lustman PJ. Depression in type 2 diabetes mellitus: prevalence, impact, and treatment. Drugs. 2015;75(6):577‒87. DOI: 10.1007/s40265-015-0347-4. PMID: 25851098.
Schmidt AM. Highlighting Diabetes Mellitus: The Epidemic Continues. Arterioscler Thromb Vasc Biol. 2018;38(1):e1‒e8. DOI: 10.1161/ATVBAHA.117.310221. PMID: 29282247.
Wormser GP, Hassett AL. Depression in the Primary Care Setting. N Engl J Med. 2019;380(23):2278‒9. DOI: 10.1056/NEJMc1903259. PMID: 31167071.
Andreev LY, Kozhemiakyn LA. Metodyka opredelenyia malonovoho dyaldehyda [Method for malonic dialdehyde determination]. Laboratornoe delo [Laboratory practice]. 1988;(11):41‒3. [In Russian].