Indicators of hemodynamic and structural heart parameters in patients with comorbid pathology
PDF (Українська)

Keywords

diabetes mellitus
hypertonic disease
diabetic nephropathy
heart remodeling
chronic kidney disease

How to Cite

Topchii, I., Semenovykh, P., Kirienko, O., Kirienko, D., Tsygankov, O., & Gridasova, L. (2021). Indicators of hemodynamic and structural heart parameters in patients with comorbid pathology. Medicine Today and Tomorrow, 90(1), 44-51. https://doi.org/10.35339/msz.2021.90.01.05

Abstract

In press

Currently, diabetes mellitus is a complex global problem, which is increasing every year. So in 2019, diabetes in the world was detected in 463 million adults (from 20 to 79 years old). And the main cause of death in patients with diabetes mellitus is cardiovascular complications. The features of functional and structural changes in the heart were studied in patients with type 2 diabetes mellitus and nephropathy. A total of 75 patients with type 2 diabetes mellitus were examined, of which 50 patients had diabetic nephropathy of varying severity. The control group consisted of 20 healthy individuals. The control group consisted of 20 practically healthy patients. After a clinical examination, depending on the state of renal function, all patients were divided into the following groups: group I consisted of 25 patients with type 2 diabetes mellitus without signs of nephropathy; group II consisted of 26 patients with type 2 diabetes mellitus with normal glomerular filtration rate and albuminuria; group III consisted of 24 patients with type 2 diabetes mellitus with decreased glomerular filtration rate and albuminuria. To study changes in hemodynamics and structural parameters of the heart, patients underwent transthoracic echocardiography on an ULTIMA PA ultrasound machine (Radmir, Ukraine) using a sectoral phased transducer with a frequency range of 2–3 MHz according to the standard technique according to the recommendations of the American Echocardiographic Society. Indicators the patients underwent anthropometric measurements. Patients with diabetic nephropathy and albuminuria and decreased glomerular filtration rate showed an increase in the linear dimensions of the heart in comparison with controls and patients without signs of nephropathy. With diabetic nephropathy patients have a significant increase in left ventricular myocardial mass and a significant increase in the detection rate of left ventricular hypertrophy up to 91.3 % in patients with albuminuria and preserved renal function and up to 100.0 % with a decrease in glomerular filtration rate.

Keywords: diabetes mellitus, hypertonic disease, diabetic nephropathy, heart remodeling, chronic kidney disease.

https://doi.org/10.35339/msz.2021.90.01.05
PDF (Українська)

References

International Diabetes Federation (2019). IDF Diabetes Atlas (9th ed.). Brussels, Belgium: International Diabetes Federation. Access mode https://www.diabetesatlas.org/en/resources/

Tsytovskyi, M. N. (2017). Statystychnyi, klinichnyi ta morfolohichnyi aspekty vplyvu tsukrovoho diabetu na stan sertsevo-sudynnoi systemy [Statistical, clinical and morphological aspects of impact of diabetes on the cardiovascular system]. Naukovyi visnyk Uzhhorodskoho universytetu. Seriia Medytsyna – Scientific Bulletin of Uzhhorod University. Series: Medicine, (1(55)), 168–177. Retrieved from: https://dspace.uzhnu.edu.ua/jspui/handle/lib/15111 [in Ukrainian].

Lang, R. M., Badano, L. P., Mor-Avi, V., Afilalo, J., Armstrong, A., Ernande, L. et al. (2015). Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Journal of the American Society of Echocardiography, 28(1), 1–39.e14. DOI: 10.1016/j.echo.2014.10.003, PMID: 25559473.

Williams, B., Mancia, G., Spiering, W., Rosei, E. A., Azizi, M., Burnier, M. et al. (2018). 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. J. Hypertens., 36(10), 1953–2041. DOI: 10.1097/HJH.0000000000001940, PMID: 30234752.

Kuzin, A. I., Vasyliev, A. A., Cherednykova, M. A., & Kamerer, O. V. (2003). Diahnostyka ta likuvannia dyslipidemii u khvorykh metabolichnym syndromom [Diagnosis and treatment of dyslipidemia in patients with metabolic syndrome]. medbib.in.ua. Access mode http://medbib.in.ua/diagnostika-lechenie-dislipidemii.html [in Ukrainian].

Typovi patolohichni protsesy. Patofiziolohiia obminu rechovyn: navchalnyi posibnyk [Typical pathological processes. Pathophysiology of metabolism: a textbook]. (2008). medbib.in.ua. Access mode http://medbib.in.ua/insulinonezavisimyiy-saharnyiy-diabet-44217.html [in Ukrainian].

Wu, N., Zhao, W., Ye, K., Li, Y., He, M., Lu, B., & Hu, R. (2014). Albuminuria is associated with left ventricular hypertrophy in patients with early diabetic kidney disease. International Journal of Endocrinology, 2014, Article 351945. DOI: 10.1155/2014/351945.

Kutyrina, I. M., Rudenko, T. E., Savelֹ’eva, S. A., Shvetsov, M. Yu., & Shestakova, M. V. (2014). Kardiorenalnyi sindrom u bolnykh khronicheskoi bolezniu pochek i saharnym diabetom [Cardiorenal syndrome in patients with chronic kidney disease and diabetes mellitus]. Saharnyi diabet – Diabetes Mellitus, 16(3), 90–96. DOI: 10.14341/2072-0351-822 [in Russian].

Bluemke, D. A., Kronmal, R. A., Lima, J. A., Liu, K., Olson, J., Burke, G. L., & Folsom, A. R. (2008). The relationship of left ventricular mass and geometry to incident cardiovascular events: the MESA (Multi-Ethnic Study of Atherosclerosis) study. J. Am. Coll. Cardiol., 52(25), 2148–2155. DOI: 10.1016/j.jacc.2008.09.014, PMID: 19095132, PMCID: PMC2706368.

Tuegel, C., & Bansal, N. (2017). Heart failure in patients with kidney disease. Heart (British Cardiac Society), 103(23), 1848–1853. DOI: 10.1136/heartjnl-2016-310794, PMID: 28716974.

Sokolov, Ye. I. (2002). Diabeticheskoie serdtse [Diabetic heart]. Moscow: Meditsina, 416 p. [in Russian].