Dynamics of biochemical indicators in the process of mucous-bone wound healing in cases of spontaneous periodontitis on the background of different organism reactivity
Vol 90 No 1 (2021), Theoretical and Experimental Medicine
Vol 90 No 1 (2021)

Dynamics of biochemical indicators in the process of mucous-bone wound healing in cases of spontaneous periodontitis on the background of different organism reactivity

Theoretical and Experimental Medicine
https://doi.org/10.35339/msz.2021.90.01.02
Published March 31, 2021
Yu.Yu. Yarov
Donetsk National Medical University of the Ministry of Health of Ukraine, Lyman
https://orcid.org/0000-0002-2867-9866
PDF (Українська)

How to Cite

Yarov, Y. (2021). Dynamics of biochemical indicators in the process of mucous-bone wound healing in cases of spontaneous periodontitis on the background of different organism reactivity. Medicine Today and Tomorrow, 90(1), 13-20. https://doi.org/10.35339/msz.2021.90.01.02
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver

Download Citation

Endnote/Zotero/Mendeley (RIS) BibTeX

Abstract

In press

The dynamics of biochemical parameters (lipid peroxidation, medium molecular peptides, prostaglandins) blood levels after periodontal tissues surgery of 24 dogs with spontaneous periodontitis has been studied. Animals were divided into groups with normal, hyper- and hyporeactivity of the body. It has been revealed that the changes of the studied biochemical parameters during normoreactivity of the organism are mutually correlated, which provides synchronization of necrotic and reparative processes in the healing of mucosal wounds after patch surgery in cases of spontaneous periodontitis. When hyperreactivity of organism is observed, the changes of indicators of lipid peroxidation, medium molecular peptides and prostaglandins promote strengthening of necrotic processes, and in cases of hyporeactivity they boost their slowing down that in both cases leads to delay of reparation in healing of an artificial mucous-bone wound.

Keywords: spontaneous periodontitis, reactivity of the organism, wound healing, biochemical parameters.

https://doi.org/10.35339/msz.2021.90.01.02
PDF (Українська)

References

Savel’eva, N. M. (2018). Rol mіkroflory v іnіtsіatsii zakhvoriuvan parodonta [The role of mi-croflora in the initiation of periodontal disease]. Ukrainskyi zhurnal medytsyny, bіolohii ta sportu – Ukrainian Journal of Medicine, Biology and Sports, 3(7(16)), 234–237. DOI: 10.26693/jmbs03.07.234 [in Ukrainian].

Slynko, Yu. O., Mіshina, M. M., & Sokolova, I. I. (2019). Sklad mіkroflory rіznykh bіotopіv porozhnyny rota u osіb іz chastkovoiu vtorynnoiu adentіieiu [Composition of microflora of different oral cavity biotops in persons with partial secondary adentia]. Ukrainskyi zhurnal medytsyny, bіolohii ta sportu – Ukrainian Journal of Medicine, Biology and Sports, 4(2(18)), 214–219. DOI: 10.26693/jmbs04.02.214 [in Ukrainian].

Lesnukhіna, G. L. (2000). Kompleksne lіkuvannia heneralіzovanoho parodontytu z korektsіieiu porushen perekysnoho okyslennia lіpіdіv [Complex treatment of generalized periodontitis with correction of disorders of lipid peroxidation]. Extended abstract of candidate’s thesis. Kyiv, 19 p. [in Ukrainian].

Moroz, K. A. (2004). Rol peroksydnoi oksydatsіi lіpіdіv u rozvytku patolohіi parodonta [The role of peroxide oxidation of lipids in the development of periodontal pathology]. Eksperymentalna ta klіnіchna fіzіolohіia і bіokhіmіia – Experimental and Clinical Physiology and Biochemistry, (2), 87–91 [in Ukrainian].

Samoilenko, A. V., & Gorshkova, A. Ye. (2020). Porіvnialna kharakterystyka lіkuvannia patsіientіv, khvorykh na khronіchnyi heneralіzovanyi parodontyt na tlі znyzhennia antyoksydantnoho zakhystu orhanіzmu [Comparative characteristics of the treatment of patients with chronic generalized periodontitis againts the background of a reduced antioxidant protection of the body]. Suchasna stomatolohіia – Modern Dentistry, (1), 52–57. DOI: 10.33295/1992-576X-2020-1-54 [in Ukrainian].

Chesnokova, A. L. (1998). Sostoianiie antiokislitelnoi sistemy bolnykh heneralizovannym parodontitom [State of the antioxidant system in patients with generalized periodontitis]. Vestnik stomatolohii – Bulletin of Dentistry, (1), 33–35 [in Russian].

Ward, P. A., Warren, J. S., & Johnson, K. S. (1988). Oxygen radicals, inflammation and tis-sue injury. Free Radic. Biol. and Med., 5(5–6), 403–408. DOI: 10.1016/0891-5849(88)90114-1.

Offenbacher, S., Heasman, P., & Collins, J. (1993). Modulation of host PGE2 secretion as a determinant of periodontal disease expression. J. Periodontol., 64(5S), 432–444. DOI: 10.1902/jop.1993.64.5s.432, PMID: 8315565.

Preshaw, P. M., & Heasman, P. A. (2002). Prostaglandin E2 concentrations in gingival crevicular fluid observations in untreated chronic periodontitis. J. Clin. Periodontol., 29(1), 15–20. DOI: 10.1034/j.1600-051x.2002.290103.x, PMID: 11846844.

Kovalevskiy, A. M., Ushakova, A. V., Kovalevskiy, V. A., & Prozhenina, E. Yu. (2018). Bakterialnaia bioplenka parodontalnykh karmanov: pereosmysleniie opyta parodontolohii [Bacterial biofilm of periodontal pockets: the revision of periodontology experience]. Parodontologiya – Perio-dontology, 23(2), 15–22. DOI: 10.25636/PMP.1.2018.2.3 [in Russian].

Saito, S., Saito, M., Ngan, P., Lanese, R., Shanfeld, J., & Davidovitch, Z. (1990). Effects of parathyroid hormone and cytokines on prostaglandin E synthesis and bone resorbtion by human periodontol ligament fibroblasts. Archs. Oral Biol., 35(10), 845–855. DOI: 10.1016/0003-9969(90)90010-8, PMID: 2176076.