Keywords
periodontal tissue
cytopathology
morphometry
epithelial cell
How to Cite
Abstract
Periodontal tissues diseases are of a multifactorial nature and depend not only on local etiological causes, but may also be due to somatic pathology. During pathological changes initiation, gingival epithelial cells are able to perform the functions of antigen-presenting cells. Of particular interest is coronary heart disease, which can lead to an imbalance in the process of differentiation of gingival epithelial cells, changes in their morphometric parameters and its quantitative increase in cells with manifestations of cytopathology. Concerning the manifestations of cell pathology and changes in the morphometric parameters of gingival epithelial cells were studied in patients with coronary heart disease. A total of 71 patients with coronary heart disease and 20 somatically healthy patients were examined. Cytological examination was performed on scrapings from the epithelium surface of the attached gingiva. It is proved that in patients with ischemic heart disease, changes in gingival epithelial cells with signs of nuclear pathology and changes in the nuclear-cytoplasmic ratio are statistically more common than in somatically healthy patients.
References
Three-dimensional stress distribution in the human periodontal ligament in masticatory, parafunctional, and trauma loads: Finite element analysis / I. A. Poiate, A. B. de Vasconcellos, R. B. de Santana, E. J. Poiate // Periodontol. – 2009. – № 80. – P. 1859–1867.
Ультраструктурна організація тканин ясен хворих на генералізований пародонтит при кардіоваскулярній патології / О. В. Копчак, Г. Ф. Білоклицька, Л. О. Стеченко, І. О. Кривошеєва // Світ медицини та біології. – 2017. – № 1. – С. 121–126.
Быкова И. А. Цитологическая характеристика отпечатков слизистой оболочки полости рта с применением индекса дифференцировки клеток / И. А. Быкова, А. А. Агаджанян, Г. В. Банченко // Лабораторное дело. – 1987. – № 1. – С. 33–35.
Histopathological and clinical expression of periodontal disease related to the systemic inflammatory response / A. Ionel, O. Lucaciu, F. Tăbăran [et al] // Histol. Histopathol. – 2017. – № 32 (4). – P. 379–384. – DOI: 10.14670/HH-11-803.
Mediators between oral dysbiosis and cardiovascular diseases / M. Pietiäinen, J. M. Liljestrand, E. Kopra, P. J. Pussinen // Eur. Journal Oral Sci. – 2018. – № 1 (26). – P. 26–36.
Aguilar A. Hypertension: Global blood pressure trends / A. Aguilar // Nat. Rev. Nephrol. – 2017. – № 13 (1). – P. 2. – DOI: 10.1038/nrneph.2016.178.
Holmlund A. Poor response to periodontal treatment may predict future cardiovascular disease / A. Holmlund, E. Lampa, L. Lind // J. Dent. Res. – 2017. – № 96 (7). – P. 768–773. – DOI: 10.1177/0022034517701901.