Гематологічні прояви Helicobacter Pylori (огляд літератури)
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Ключові слова

виразка шлунку
залізодефіцитна анемія
імунна тромбоцитопенічна пурпура
MALT-лімфома

Як цитувати

Козлова , Ю., & Говтва , Д. (2023). Гематологічні прояви Helicobacter Pylori (огляд літератури). Медицина сьогодні і завтра, 92(1), 16-24. https://doi.org/10.35339/msz.2023.92.1.kog

Анотація

Відомо, що Helicobacter pylori є ключовим фактором в етіології різних шлунково-кишкових захворювань, починаючи від хронічного гастриту без клінічних симптомів і закінчуючи пептичною виразкою, аутоімунним гастритом, аденокарциномою та MALT-лімфомою шлунку. Проте сучасні дослідження вказують на те, що Helicobacter pylori може бути пов’язаний з численними позашлунковими захворюваннями, які призводять до хронічного локального або системного запалення та ініціації аутоімунних реакцій, в тому числі й до гематологічних. В статті наведено роль CagA Helicobacter pylori в патогенезі залізодефіцитної анемії, імунної тромбоцитопенічної пурпури і MALT-лімфоми. Встановлено, що наявність саме протеїну CagA в штамі Helicobacter pylori є ключовим для розвитку запалення і пухлинної трансформації. Розкриття цих механізмів необхідні для більш точного розуміння деяких патологічних процесів, що викликає ця бактерія, як в шлунку, так і поза ним. Це допоможе покращити діагностику, спрямувати лікування і передбачити клінічний прогноз.

Ключові слова: виразка шлунку, залізодефіцитна анемія, імунна тромбоцитопенічна пурпура, MALT-лімфома.

https://doi.org/10.35339/msz.2023.92.1.kog
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Посилання

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