Keywords
cholecystectomy
obesity
membrane destructive phenomena
postoperative period
How to Cite
Abstract
Since the intensity of membrane-destructive phenomena largely depends on disorders of lipid metabolism, which occur in people even with a normal body mass index, for obese patients it is even more reasonable to use drugs that are able to regulate lipid metabolism in the early postoperative period. The effect of sodium succinate megluminate on the postoperative period was studied in 20 patients (7 men and 13 women) with a body mass index over 30 kg/m2 who underwent laparoscopic cholecystectomy. The age of the subjects ranged from 40 to 60 years, the body weight was from 95 to 103 kg. The patients were divided into two groups: I group consists of 10 patients who received meglumine sodium succinate in the postoperative period; II group consists of 10 patients who did not receive meglumine sodium succinate in the postoperative period. It has been shown that the use of the antioxidant meglumine sodium succinate in the treatment of patients (group I) with acute cholecystitis with obesity in the early postoperative period leads to positive clinical and laboratory dynamics (after the first dose of the drug), one of the indicators of which is a reduction in hospital stay by 2.29 bed-days. Against the background of the use of meglumine sodium succinate, the indicators of the antioxidant system increase almost several times, and the indicators of the peroxide chain reaction decrease already on the first day and have values close to normal. The use of the antioxidant meglumine sodium succinate in the complex treatment of obese patients who underwent cholecystectomy makes it possible to optimize the early postoperative period.
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