Influence of HIV infection and alcohol abuse on the morphological structure of the uterine tube

Abstract

Chronic alcoholism and HIV infection inevitably worsen the prognosis of the course of any pathology. The aim of our work was to determine the influence of HIV infection and alcohol abuse on the morphological structure of fallopian tubes. To achieve the goal, sectional material was selected from 50 women, who were divided into two groups. The first (main) group included 25 women who were HIV-infected and abused alcohol. The control group consisted of sectional material of 25 women without HIV infection and alcohol addiction. As a result of the study, it was determined that the presence of chronic alcoholism in HIV-infected women significantly affects both the morphometric parameters of the fallopian tube and its histological structure. Significant pathological changes are determined in each of the studied indicators. It was found that in the main group compared to the control group, the length of the ampullary section decreases (from [79.47±0.51]×10^-3 m to [69.91±0.78]×10^-3 m), the outer diameter in the area of the transition of the isthmus to the ampullary department (from [6.81±0.23]×10^-3 m to [5.66±0.38]×10^-3 m), the area of the lumen of the ampullary department decreases (from [9.44±0.44]×10^-6 m² to [7.66±0.55]×10^-6 m²); the height of the epithelial layer, measured histologically, is also reduced (from [92.01±4.03]×10^-6 m to [65.41±3.20]×10^-6 m); the volume of connective tissue in the muscle layer, on the contrary, increased (from [5.61±1.01]% to [17.39±3.81]%). It was concluded that the combination of chronic alcoholism and HIV infection in women can to cause sharply pronounced irreversible changes in both the macro- and microscopic structure of the organ under study.

Keywords: HIV infection, chronic alcoholism, fallopian tube.