Influence of HIV infection and alcohol abuse on the morphological structure of the uterine tube
PDF (Українська)

Keywords

HIV infection
chronic alcoholism
fallopian tube

How to Cite

Lytvynenko , M. (2021). Influence of HIV infection and alcohol abuse on the morphological structure of the uterine tube. Medicine Today and Tomorrow, 90(3), 6-12. https://doi.org/10.35339/msz.2021.90.3.lyt

Abstract

Chronic alcoholism and HIV infection inevitably worsen the prognosis of the course of any pathology. The aim of our work was to determine the influence of HIV infection and alcohol abuse on the morphological structure of fallopian tubes. To achieve the goal, sectional material was selected from 50 women, who were divided into two groups. The first (main) group included 25 women who were HIV-infected and abused alcohol. The control group consisted of sectional material of 25 women without HIV infection and alcohol addiction. As a result of the study, it was determined that the presence of chronic alcoholism in HIV-infected women significantly affects both the morphometric parameters of the fallopian tube and its histological structure. Significant pathological changes are determined in each of the studied indicators. It was found that in the main group compared to the control group, the length of the ampullary section decreases (from [79.47±0.51]×10-3 m to [69.91±0.78]×10-3 m), the outer diameter in the area of the transition of the isthmus to the ampullary department (from [6.81±0.23]×10-3 m to [5.66±0.38]×10-3 m), the area of the lumen of the ampullary department decreases (from [9.44±0.44]×10-6 m2 to [7.66±0.55]×10-6 m2); the height of the epithelial layer, measured histologically, is also reduced (from [92.01±4.03]×10-6 m to [65.41±3.20]×10-6 m); the volume of connective tissue in the muscle layer, on the contrary, increased (from [5.61±1.01]% to [17.39±3.81]%). It was concluded that the combination of chronic alcoholism and HIV infection in women can to cause sharply pronounced irreversible changes in both the macro- and microscopic structure of the organ under study.

Keywords: HIV infection, chronic alcoholism, fallopian tube.

https://doi.org/10.35339/msz.2021.90.3.lyt
PDF (Українська)

References

Jepsen P. Comorbidity in cirrhosis. World J Gastroenterol. 2014;20(23):7223-30. DOI: 10.3748/wjg.v20.i23.7223. PMID: 24966593.

Whiteside A, Wilson D. Health and AIDS in 2019 and beyond. Afr J AIDS Res. 2018;17(4):iii-v. DOI: 10.2989/16085906.2018.1550202. PMID: 30560731.

Abdool Karim Q, Abdool Karim SS. HIV-No time for complacency. Science. 2018;360(6394):1153. DOI: 10.1126/science.aau2663. PMID: 29903942.

Duda P, Knysz B, Gąsiorowski J, Szetela B, Piotrowska E, Bronkowska M. Assess-ment of dietary habits and lifestyle among people with HIV. Adv Clin Exp Med. 2020;29(12):1459-67. DOI: 10.17219/acem/128234. PMID: 33389836.

Edelman EJ, Williams EC, Marshall BDL. Addressing unhealthy alcohol use among people living with HIV: recent advances and research directions. Curr Opin Infect Dis. 2018;31(1):1-7. DOI: 10.1097/QCO.0000000000000422. PMID: 29176446.

Fama R, Le Berre AP, Sullivan EV. Alcohol's Unique Effects on Cognition in Wom-en: A 2020 (Re)view to Envision Future Research and Treatment. Alcohol Res. 2020;40(2):03. DOI: 10.35946/arcr.v40.2.03. PMID: 32923307.

Roan NR, Jakobsen MR. Friend or Foe: Innate Sensing of HIV in the Female Repro-ductive Tract. Curr HIV/AIDS Rep. 2016;13(1):53-63. DOI: 10.1007/s11904-016-0305-0. PMID: 26879654.

Wick MR. The hematoxylin and eosin stain in anatomic pathology-An often-neglected focus of quality assurance in the laboratory. Semin Diagn Pathol. 2019;36(5):303-11. DOI: 10.1053/j.semdp.2019.06.003. PMID: 31230963.

Stringer EM, Kendall MA, Lockman S, Campbell TB, Nielsen-Saines K, Sawe F, et al. Pregnancy outcomes among HIV-infected women who conceived on antiretroviral ther-apy. PLoS One. 2018;13(7):e0199555. DOI: 10.1371/journal.pone.0199555. PMID: 30020964.

Williams B, Landay A, Presti RM. Microbiome alterations in HIV infection a re-view. Cell Microbiol. 2016;18(5):645-51. DOI: 10.1111/cmi.12588. PMID: 26945815.

Green A. The HIV response in Ukraine: at a crossroads. Lancet. 2017;390:347-8. DOI: 10.1016/S0140-6736(17)31915-3.

Beloukas A, Psarris A, Giannelou P, Kostaki E, Hatzakis A, Paraskevis D. Molecular epidemiology of HIV-1 infection in Europe: An overview. Infect Genet Evol. 2016;46:180-9. DOI: 10.1016/j.meegid.2016.06.033. PMID: 27321440.

Bbosa N, Kaleebu P, Ssemwanga D. HIV subtype diversity worldwide. Curr Opin HIV AIDS. 2019;14(3):153-60. DOI: 10.1097/COH.0000000000000534. PMID: 30882484.

Arimi MM, Nyachieo A, Langat DK, Abdi AM, Mwenda JM. Evidence for expres-sion of endogenous retroviral sequences on primate reproductive tissues and detection of cross-reactive ERVS antigens in the baboon ovary: a review. East Afr Med J. 2006;83(2):106-12. DOI: 10.4314/eamj.v83i2.9397. PMID: 16708883.

Agboghoroma CO. Gynaecological and reproductive health issues in HIV-positive women. West Afr J Med. 2010;29(3):135-42. DOI: 10.4314/wajm.v29i3.68209. PMID: 20665454.

Lytvynenko M, Bondarenko A, Gargin V. The effect of alcohol on ovarian state in HIV-infected women. Azerbaijan Med J. 2021;(1):61-8. DOI: 10.34921/amj.2021.1.008.

Lytvynenko M, Shkolnikov V, Bocharova T, Sychova L, Gargin V. Peculiarities of proliferative activity of cervical squamous cancer in HIV infection. Georgian Med News. 2017;(270):10-5. PMID: 28972476.

Gargin V, Radutny R, Titova G, Bibik D, Kirichenko A, Bazhenov O. Application of the computer vision system for evaluation of pathomorphological images. 2020 IEEE 40th International Conference on Electronics and Nanotechnology, ELNANO 2020 ‒ Proceedings. 2020:469-73. DOI: 10.1109/ELNANO50318.2020.9088898.