Keywords
complications
microbiocenosis
protective mechanisms of the oral cavity
How to Cite
Abstract
In press
The study was performed on 59 orthodontic patients who underwent tooth extraction surgery. In 30 of them (the main group) the drug complex was used, and in 29 (comparison group) the tooth extraction operation was performed without any additional actions. Pharmacological correction included vitamin-mineral complex, immunomodulator, probiotic chewing pills "BioGaya ProDentis" for 1 month. Examinations of children took place before the start of medication and after tooth extraction surgery for 3–4 and 6–7 days. The level of lysozyme activity in the oral fluid of children was determined according to the method of G. Gorin in the modification of A.P. Levitsky and O.O. Zhigina, the content of sIgA, IgA, IgG – by simple radial immunodiffusion, the concentration of IL-1β and IL-4 – by enzyme-linked immunosorbent assay. A microbiological study was also performed.
The use of pharmacological complex for the prevention and treatment of post-extraction complications in orthodontic patients for microbial, immune and antioxidant background correction showed a pronounced clinical effect, manifested by the absence of any complications from maxillofacial tissues and probably lower intensity of such clinical signs, redness and swelling.
The microbiocenosis of the oral cavity of children who used our proposed means during the surgical stage of orthodontic treatment, showed quantitative and qualitative changes, which was a prerequisite for the normal course of the wound process. Examination of the oral fluid of children who underwent orthodontic surgery on the background of pharmacological correction, showed the restoration of its protective functions (increased lysozyme activity, sIgA levels, IL-4 concentration), which resulted in a postoperative period without complications.
Keywords: tooth extraction surgery, complications, microbiocenosis, protective mechanisms of the oral cavity.
References
Salah, S.M., Temejza, & Romanovskaya, A.P. (2010). Tret'i molyary – vozmozhnye istochniki oslozhnenij [Third molars are possible sources of complications]. Tavricheskij medi-ko-biologicheskij vestnik, 4, 164-166 [in Russian].
Bouloux, G. F., Busaidy, K. F., Beirne, O. R., Chuang, S. K., & Dodson, T. B. (2015). What is the risk of future extraction of asymptomatic third molars? A systematic review. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 73(5), 806–811. PMID: 25631864. DOI: 10.1016/j.joms.2014.10.029.
Lamont, R.J., Hajishengallis, G.N., Koo, H.(M.), & Jenkinson, H.F. (2019). Oral Mi-crobiology and Immunology. 3rd ed. USA: ASM Books (Wiley). 480 p.
Carev, V.N., Davydova, M.M., Nikolaeva, E.N., Pokrovskij, V.N., Pozharskaya, V.O., Plahtij, L.Ya, [et al.] (2013). Mikrobiologiya, virusologiya i immunologiya polosti rta [Microbi-ology, virology and immunology of the oral cavity]. Moskva: GEOTAR-Media. 576 p. [in Rus-sian].
Levic'kij, A.P., Makarenko, O.A., Selivanskaya, I.A., … & Pochtar', V.N. [et al.] (2007). Fermentativnyj metod opredeleniya disbioza polosti rta dlya skrininga pro- i prebiotikov [Enzymatic method for determining oral dysbiosis for screening of pro- and prebiotics]. Kyjiv. 23 p. [in Russian].
Kuznecova, L.V., Babadzhan, V.D., Frolov, V.M., & Kravchun, P.G. (2012). Klіnіchna ta laboratorna іmunologіya [Clinical and laboratory immunology]. Kyiv: Poligraf plius. 922 p. [in Ukrainian].
Bergey, D. H., & Holt, J. G. (1994). Bergey’s manual of determinative bacteriology. (9th ed. / [edited by] John G. Holt ... [et al.].). Baltimore: Williams & Wilkins. 787 p.