Keywords
kinin-kallikrein system
cytokine status
surgical treatment
How to Cite
Abstract
The cytokine status was studied in 64 patients with neck injuries and damage to internal structures. Severe trauma causes damage to the protective barriers of the organism and activates immunological reaction. Among substances secreted during this process pro-inflammatory cytokines are of high importance. It is shown, that monitoring of cytokine status (IL-6, IL-8, IL-10, TNFα) in the acute period of trauma had been having important clinical, prognostic and diagnostic values. A dynamic study of the concentrations of pro-inflammatory and anti-inflammatory interleukins during the first ten days in patients, together with clinical data, made it possible to change the routine treatment tactics and optimize the terms and scope of surgical care. The TNFα is a reliable indicator of a developing infectious complication and takes a chance to change antibacterial or anti-inflammatory therapy and improve effects of therapy.
References
Cruvinel Neto J., Dedivitis R.A. (2011). Prognostic factors of penetrating neck trauma. Braz. J. Otorhinolaryngol., vol. 77, № 1, pp. 121–124.
Deneve Jeremiah L., Shantha Jessica G., Page Andrew J., Wyrzykowski Amy D. et al. (2010). CD4 count is predictive of outcome in LI1V-positive patients undergoing abdominal operations. The American Journal of Surgery, vol. 200, № 6, pp. 694–700.
Bogliolo G., Ierfone N., Brini C., Di Fulvio A., Stragapede R.A., Martino G., Grimaldi F. (2002). Esophageal perforations and fistulas: clinical management. G. Chir., vol. 23, № 10, pp. 394–400.
Karkos Peter D., Leong Samuel C., Beer Helen, Apostolidou Maria T., Panarese Alessandro (2007). Challenging airways in deep neck space infections. American Journal of Otolaryngology, vol. 28, № 6, pp. 415–418, DOI 10.1016/j.amjoto.2006.10.012.
Pompili A., Canitano S., Caroli F., Caterino M., Crecco M., Raus L., Occhipinti E. (2002). Asymptomatic esophageal perforation caused by late screw migration after anterior cervical plating: report of a case and review of relevant literature. Spine, vol. 27, № 23, pp. 499–502.
Hsieh C.H., Su L.T., Wang Y.C., Fu C.Y., Lo H.C., Lin C.H. (2013). Does alcohol intoxication protect patients from severe injury and reduce hospital mortality? The association of alcohol consumption with the severity of injury and survival in trauma patients. Am. Surg., vol. 79 (12), pp. 1289–1294.
Koehler S.A., Shakir A., Williams K.E. (2011). Accidental through and through penetrating injury to the neck. Am. J. Forensic. Med. Pathol., vol. 32, № 1, pp. 17–19.
Inaba K., Branco B.C., Menaker J., Scalea T.M., Crane S., DuBose J.J et al. (2012). Evaluation of multidetector computed tomography for penetrating neck injury: a prospective multicenter study. J. Trauma Acute Care Surg., vol. 72, № 3, pp. 576–583, DOI 10.1097/TA.0b013e31824badf7.
Melis M., Zawawi K., al-Badawi E., Lobo S.L., Mehta N. (2002). Complex regional pain sindrome in the head and neck: a review of the literature. J. Orofacial Pain, № 16, pp. 93–104.
Brennan J., Lopez M., Gibbons M.D., Hayes D., Faulkner J., Dorlac W.C., Barton Ch. (2011). Penetrating neck trauma in operation iraqi freedom. Otolaryngol. Head. Neck Surg., vol. 144, № 2, pp. 180–185.
Acar G.O., Tekin M., Cam O.H., Kaytanci E. (2013). Larynx, hypopharynx and mandible injury due to external penetrating neck injury. Ulus Travma Acil. Cerrahi. Derg., vol. 19, № 3, pp. 271–273.