Keywords
osteoarthrosis
cytokines
tumor necrosis factor-α
interleukin-1β
How to Cite
Abstract
The relationships between the concentration of interleukin-1β and tumor necrosis factor-α, and assess their impact on carbohydrate metabolism have been studied in patients with type 2 diabetes mellitus and its combination with osteoarthrosis. 48 patients (15 men and 33 women), mean age – (55,91±1,04), with type 2 diabetes mellitus, and its combination with osteoarthrosis and 20 healthy individuals were examined. The significant increase in the content of these cytokines and the presence of significant correlations between them and carbohydrate metabolism in the studied patients were determined. It is shown, that increased levels of interleukin-1β and tumor necrosis factor-α in the blood, their direct interaction and the relationship of these cytokines with carbohydrate metabolism makes it possible to assume that they are additional indicators of the progression of metabolic changes and aggravation of the insulin resistance.
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