Role of transforming growth factor TGF-β1 and regulatory T-lymphocytes CD4+CD25+FoxP3+ in tumor growth
Vol 70 No 1 (2016), Oncology
Vol 70 No 1 (2016)

Role of transforming growth factor TGF-β1 and regulatory T-lymphocytes CD4+CD25+FoxP3+ in tumor growth

Oncology
Published February 29, 2020
E. Kuzmenko
State Institution “Institute of Medical Radiology named after S.P. Grigoryev NAMS of Ukraine"
P. Sorochan
State Institution “Institute of Medical Radiology named after S.P. Grigoryev NAMS of Ukraine"
G. Kulinich
State Institution “Institute of Medical Radiology named after S.P. Grigoryev NAMS of Ukraine"
V. Kulinich
State Institution “Institute of Medical Radiology named after S.P. Grigoryev NAMS of Ukraine"
V. Shevtsov
State Institution “Institute of Medical Radiology named after S.P. Grigoryev NAMS of Ukraine"
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Keywords

transforming growth factor
regulatory T-lymphocytes
antineoplastic immunity
an immunotherapy

How to Cite

Kuzmenko, E., Sorochan, P., Kulinich, G., Kulinich, V., & Shevtsov, V. (2020). Role of transforming growth factor TGF-β1 and regulatory T-lymphocytes CD4+CD25+FoxP3+ in tumor growth. Medicine Today and Tomorrow, 70(1), 72–80. Retrieved from https://msz.knmu.edu.ua/article/view/419
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Abstract

Data on a role of the transforming growth factor (TGF-β1) and regulatory T-lymphocytes (CD4+CD25+FoxP3+) with a tumoral growth are presented in the review. The TGF-β1 function in immune system is connected with activity of regulatory T-lymphocytes (Treg). TGF-β1 makes the stimulating impact on a differentiation of Treg-cages on the periphery, is an effector cytokine of these cages and causes their supressible properties. In the review data on functional interrelation of TGF-β1 and Treg-cages in regulation of antineoplastic immunity and the main mechanisms of induction of T-regulatory activity with participation of TGF-β are generalized. Modern approaches in the immunotherapies focused on modulation by means of Treg.

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References

A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2 / B. L. Loeys, J. Chen, E. R. Neptune [et al.] // Nat. Genet. – 2005. – V. 37. – P. 275–281.

Santibanez J. F. TGF-β/TGF-β receptor system and its role in physiological and pathological conditions / J. F. Santibanez, M. Quintanilla, C. Bernabeu // Clin. Sci. – 2011. – V. 121. – P. 233–251.

Cancer statistics, 2009 / A. Jemal, R. Siegel, E. Ward [et al.] // Cancer Journal for Clinicians. – 2009. – V. 59. – P. 225–249.

Unmasking immunosurveillance against a syngeneic colon cancer by elimination of CD4+ NKT regulatory cells and IL-13 / J. M. Park, M. Terabe, L. T. Broeke [et al.] // Int. J. Cancer. – 2004. – V. 114. – P. 80–87.

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid / C. M. Sun, J. A. Hall, R. B. Blank [et al.] // J. Exp. Med. – 2007. – V. 204. – P. 1775–1785.

Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses / S. Sakaguchi // Annu. Rev. Immunol. – 2004. – V. 22. – P. 531–562.

Yi J. S. T cell exhaustion: characteristics, causes and conversion / J. S. Yi, M. A. Cox, A. J. Zajac // Immunology. – 2010. – V. 129. – P. 474–481.

Plasma transforming growth factor-beta1 level before radiotherapy correlates with long term outcome of patients with lung carcinoma / F. Kong, R. L. Jirtle, D. H. Huang [et al.] // Cancer. – 2000. – V. 86. – P. 1712–1719.

Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal / C. C. Zhang, A. D. Steele, S. Lindquist, H. F. Lodish // Proc. Natl. Acad. Sci. USA. – 2006. – V. 103, № 7. – P. 2184–2189.

Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor / T. Yamaguchi, K. Hirota, K. Nagahama [et al.] // Immunity. – 2007. – V. 27. – P. 145–159.

Inhibition of CD4(+)25+T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide / M. E. Lutsiak, R. T. Semnani, R. De Pascalis [et al.] // Blood. – 2005. – V. 105. – P. 2862–2868.

Wan Y. Y. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression / Y. Y. Wan, R. A. Flavell // Nature. – 2007. – V. 15, № 445 (7129). – P. 766–770.

Natural and induced CD4+CD25+ cells educate CD4+CD25-cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10 / S. G. Zheng, J. H. Wang, J. D. Gray [et al.] // J. Immunol. – 2004. – V. 172. – P. 5213–5221.

Роль трансформирующего ростового фактора TGF-β1 в патогенезе рака молочной железы / Н. Н. Бабышкина, Е. А. Малиновская, М. Н. Стахеева [и др.] // Сибир. онкологич. журнал. – 2010. – № 6. – С. 63–70.

Transforming growth factor beta-1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components, Smad2 and Runx2 / N. Selvamurugan, S. Kwok, T. Alliston [et al.] // J. Biol. Chem. – 2004. – V. 279. – P. 19327–19334.

Jones J. A. Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis / J. A. Jones, F. G. Spinale, J. S. Ikonomidis // J. Vasc. Res. – 2009. – V. 46. – P. 119–137.

Effects of transforming growth factor-β3 and matrix metalloproteinase-3 on the pathogenesis of chronic mitral valvular disease in dogs / K. Obayashi, S. Miyagawa-Tomita, H. Matsumoto [et al.] // Am. J. Vet. Res. – 2011. – V. 72. – P. 194–202.

Houghton A. N. Immune recognition of self in immunity against cancer / A. N. Houghton, J. A. Guevara-Patino // J. Clin. Invest. – 2004. – V. 114. – P. 468–471.

Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses / S. Sakaguchi // Annu. Rev. Immunol. – 2004. – V. 22. – P. 531–562.

A role for TGF-β in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood / S. Yamagiwa, J. D. Gray, S. Hashimoto, D. A. Horwitz // J. Immunol. – 2001. – V. 166. – P. 7282–7289.

Vignali D. A. How regulatory T cells work / D. A. Vignali, L. W. Collison, C. J. Workman // Nat. Rev. Immunol. – 2008. – V. 8. – P. 523–532.

TGF-beta 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells / N. Hagimoto, K. Kuwano, I. Inoshima [et al.] // J. Immunol. – 2002. – V. 168. – P. 6470–6478.

Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo / C. E. Tadokoro, G. Shakhar, S. Shen [et al.] // J. Exp. Med. – 2006. – V. 203. – P. 505–511.

Nakamura K. Cell contact-dependent immunosuppression by CD4+CD25+ regulatory T cells is mediated by cell surface-bound transforming growth factor beta / K. Nakamura, A. Kitani, W. Strober // J. Exp. Med. – 2001. – V. 194. – P. 629–644.

Polarization of tumor-associated neutrophil phenotype by TGF-β: «N1» versus «N2» TAN / Z. G. Fridlender, J. Sun, S. Kim [et al.] // Cancer Cell. – 2009. – V. 16. – P. 183–194.

CD4+CD25+ T cells responding to serologically defined autoantigens suppress antitumor immune responses / H. Nishikawa, T. Kato, K. Tanida [et al.] // Proc. Natl. Acad. Sci USA. – 2003. – V. 100. – P. 10902–10906.

Stimulation of CD25+CD4+ regulatory T cells through GITR break immunological self-tolerance / J. Shimizu, S. Yamazaki, T. Takahashi [et al.] // Nat. Immunol. – 2002. – V. 3. – P. 135–142.

The role of regulatory T lymphocytes in the induced immune response mediated by biological vaccines / M. Lopez, R. Aguilera, C. Perez [et al.] // Immunobiology. – 2006. – V. 211. – P. 127–136.

Deshpande P. L. Cutting edge: CNS CD11c+ cells from mice with encephalomyelitis polarize Th17 cells and support CD25+CD4+ T cell-mediated immunosuppression, suggesting dual roles in the disease process / P. L. Deshpande, I. L. King, B. M. Segal // J. Immunol. – 2007. – V. 178. – P. 6695–6699.

Wahl S. M. TGF-beta: a mobile purveyor of immune privilege. / S. M. Wahl, J. Wen, N. Moutsopoulos // Immunol. Rev. – 2006. – V. 213. – P. 213–227.

Echocardiographic myocardial imaging reveals segmental cardiomyopathy in Churg–Strauss syndrome / A. Vitarelli, L. Capotosto, E. Rosato [et al.] // Texas Heart Inst. J. – 2010. – V. 37. – P. 594–597.

Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions / N. Hiraoka, K. Onozato, T. Kosuge, S. Hirohashi // Clin. Cancer Res. – 2006. – V. 12. – P. 5423–5434.

Tumor evasion of the immune system by converting CD4+CD25− T cells into CD4+CD25+ T regulatory cells: role of tumor-derived TGF-β / V. C. Liu, L. Y. Wong, T. Jang [et al.] // J. Immunol. – 2007. – V. 178. – P. 2883–2892.

Li M. O. T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation / M. O. Li, Y. Y. Wan R. A. Flav // Immunity. – 2007. – V. 26, № 5. – P. 579–591.

Transforming growth factor-β regulation of immune responses / M. O. Li, Y. Y. Wang, S. Sanjabi [et al.] // Annu. Rev. Immunol. – 2006. – V. 24. – P. 99–146.

CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages / D. G. DeNardo, J. B. Barreto, P. Andreu [et al.] // Cancer Cell. – 2009. – V. 16. – P. 91–102.

Expression of ICOS on human melanoma-infiltrating CD4+CD25highFoxp3+ T regulatory cells: implications and impact on tumor-mediated immune suppression / L. Strauss, C. Bergmann, M. J. Szczepanski [et al.] // J. Immunol. – 2008. – V. 180, № 5. – P. 2967–2980.

TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer / C. C. Ho, W. Y. Liao, C. Y. Wang [et al.] // Am. J. Respir. Crit. Care Med. – 2008. – V. 177. – P. 763–770.

Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer / B. Almand, J. I. Clark, E. Nikitina [et al.] // J. Immunology. – 2001. – V. 166. – P. 678–689.

Nowak A. Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors / A. Nowak, B. Robinson, R. Lake // Cancer Res. – 2003. – V. 63. – P. 4490–4496. 41. IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage / A. O’Garra, P. L. Vieira, P. Viera [et al.] // J. Clin. Invest. – 2004. – V. 114. – P. 1372–1378.

Presence of low dose of fludarabine in cultures blocks regulatory T cell expansion and maintains tumorspecific cytotoxic T lymphocyte activity generated with peripheral blood lymphocytes / U. Hegde, A. Chhabra, S. Chattopadhyay [et al.] // Pathobiology. – 2008. – V. 75, № 3. – P. 200–208.

The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells / C. Galustian, B. Meyer, M. C. Labarthe [et al.] // Cancer Immunol. Immunother. – 2008. – V. 57. – P. 1553–1558.

Immunologic self-tolerance maintained by CD25+CD4+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen / T. Takahashi, T. Tagami, S.Yamazaki [et al.] // J. Exp. Med. – 2000. – V. 192. – P. 303–310.

Regulatory T cells in human disease and their potential for therapeutic manipulation / L. S. Taams, D. B. Palmer, A. N. Akbar [et al.] // Immunology. – 2006. – V. 118. – P. 1–9.

Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses / S. Sakaguchi // Annu. Rev. Immunol. – 2004. – V. 22. – P. 531–562.

Park H. B. Acquisition of anergic and suppressive activities in transforming growth factor-beta-costimulated CD4+CD25- T cells / H. B. Park // Int. Immunol. – 2004. – V. 16. – P. 1203–1213.

Altering regulatory T cell function in cancer immunotherapy: a novel means to boost the efficacy of cancer vaccines / J. Ruter, B. G. Barnett, I. Kryczek [et al.] // Front Biosci. – 2009. – V. 14. – P. 1761–1770.

Шевцов М. А. Иммунотерапия в клинической онкологии: новые парадигмы в создании противораковых вакцин / М. А. Шевцов, Б. А. Маргулис, В. А. Хачатрян // Нейрохирургия и неврология. – 2012. – Т. 34, № 4. – C 94–105.

Kim J. M. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice / J. M. Kim, J. P. Rasmussen, A. Y. Rudensky // Nat. Immunol. – 2007. – V. 8. – P. 191–197.

Role of SEREX-defined immunogenic wild-type cellular molecules in the development of tumor-specific immunity / H. Nishikawa, K. Tanida, H. Ikeda [et al.] // Proc. Natl. Acad. Sci. USA. – 2001. – V. 98. – P. 14571–14576.

CD4+CD25+ T cells responding to serologically defined autoantigens suppress antitumor immune responses / H. Nishikawa, T. Kato, K. Tanida [et al.] // Proc. Natl. Acad. Sci. USA. – 2003. – V. 100 (19). – P. 10902–10906.

Manoukian G. Denileukin diftitox: a novel immunotoxin / G. Manoukian, F. Hagemeister // Expert Opin Biol. – 2009. – V. 9. – P. 1445–1451.

Enhancement of vaccinemediated antitumor immunity in cancer patient’s afterdepletion of regulatory T cells / J. Dannull, Zhen Su, D. Rizzieri [et al.] // J. Clin. Invest. – 2005. – V. 115. – P. 3623–3633.

Влияние терапии Аллокином-альфа на течение рецидивов хронического генитального герпеса / Ф. И. Ершов, А. А. Кубанова, Б. В. Пинегин [и др.] // Деловые партнеры. – 2003. – Т. 40, № 4. – С. 103–111.