Abstract
It has been studied prognosis of threatened abortion in women of reproductive age taking into account progesterone receptor gene polymorphism (SNP PGR) rs590688. Statistically significant predictors of this pathology development are stress level on a scale of Perceived Stress Scale and single nucleotide polymorphism of progesterone receptor gene (SNP PGR) rs590688. Homozygous carriers of G-allele SNP PGR rs590688 is associated with an increased risk of threatened abortion in 2,5 times.
References
Зоря О. П. Демографічний стан в Україні в умовах глибокої трансформаційної економічної кризи / О. П. Зоря // Грані. – 2015. – № 2 (118). – С. 89–92.
Saraswat L. Maternal and perinatal outcome in women with threatened miscarriage in the first trimester: a systematic review / L. Saraswat, S. Bhattacharya // BJOG. – 2010. – № 117. – P. 245–257.
Basama F. The outcome of pregnancies in 182 women with threatened miscarriage / F. Basama, F. Crosfill // Arch. Gynecol. Obstet. – 2004. – № 270. – С. 86–90.
Ozdemirci S. Influence of threatened miscarriage on pregnancy and early postpartum period: a case-control report / S. Ozdemirci, E. Karahanoglu // J. Matern. Fetal. Neonatal. Med. – 2015. – № 28. – P. 1186–1189.
Лихачев В. Практичне акушерство з невідкладними станами / В. Лихачев. – Полтава : Медичне інформаційне агентство, 2010. – 720 с.
Al-Asmakh M. Reproductive functions of progesterone / M. Al-Asmakh // Middle East Fertility Society J. – 2007. – V. 12, № 3. – P. 197–201.
Graham J. Physiological action of progesterone in target tissues / J. Graham, C. Clarke // Endocrine. – 1997. – № 18. – P. 502–519.
Romano A. The PROGINS polymorphism of the human progesterone receptor diminishes the response to progesterone / A. Romano, B. Delvoux, D. Fischer // J. Mol. Endocrinol. – 2007. – № 38. – P. 331–350.
Guoyang L. Single nucleotide polymorphisms in the human progesterone receptor gene and spontaneous preterm birth / L. Guoyang, T. Morgan, M. Bahtiyar // Reprod. Sci. – 2008. – № 15. – P. 147–155.
Mills A. Characterization of progesterone receptor isoform expression in fetal membranes / A. Mills, B. Yonish // Am. J. Obstet. Gynecol. – 2006. – № 195. – P. 998–1003.
Manuck T. Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth / T. Manuck, M. Esplin, J. Biggio // Am. J. Obstet. Gynecol. – 2016. – № 214. – P. 376.
Kryvopustov O. Single nucleotide polymorphisms in human progesterone receptor gene and its value in miscarriage or preterm delivery / O. Kryvopustov, V. Dosenko // Fiziol. Zh. – 2015. – № 61. – P. 111–119.
Su M. Association of progesterone receptor polymorphism with idiopathic recurrent pregnancy loss in Taiwanese Han population / M. Su, I. Lee, Y. Chen // J. Assist. Reprod. Genet. – 2011. – № 28. – P. 239–243.