Keywords
obesity
osteoporosis
mineral metabolism
How to Cite
Abstract
The features of calcium-phosphorous metabolism have been in 98 patients with coronary artery disease, depending on the body mass index and the correlation between the mineral and lipid metabolism has been evaluate. Patients with CAD were divided into groups depending on the degree of obesity. The control group included 20 healthy people of the same sex and age. The parameters of the mineral metabolism of blood serum were not higher than the reference norms, however they were significantly higher in patients with CAD and obesity I–II in comparison with other groups. The rates of mineral metabolism in daily urine were significantly higher in patients with CAD and obesity II. Consequently, the comorbidity of CAD and obesity is a high risk of developing osteodeficiency states, which is confirmed by early changes in the parameters of calcium-phosphorus metabolism, but overweight in patients with CAD can «provide» a protective effect on the development of osteodeficiency.
References
Сardiovascular diseases (CVDs) [digital resource] / WHO. – Available from :
http://www.who.int/en/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds).
Obesity rank by countries [digital resource]. – Available from :
https://renewbariatrics.com/obesity-rank-by-countries/.
Osteoporosis national foundation [digital resource]. – Available from :
Atherosclerosis and osteoporosis: age-dependent degenerative processes or related entities? / P. Anagnostis, A. Karagiannis, A. I. Kakafika [et al.] // Osteoporos Int. – 2009. – Feb. – Vol. 20 (2). – P. 197–207.
Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes / J. Divers, T. C. Register, C. D. Langefeld, L. E. Wagenknecht // J. Bone Miner Res. – 2011. – Jul. – Vol. 26 (7). – P. 1554–1560.
Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study / B. I. Freedman, D. W. Bowden, J. T. Ziegler [et al.] // J. Bone Miner. Res. – 2009. – Oct. – Vol. 24 (10). – 1719–1727.
Correlation between osteoporosis and cardiovascular diseases / Delia Sprini, Giovam Battista Rini, Laura Di Stefano [et al.] // Clin. Cases Miner. Bone Metab. –2014. – May–Aug. – Vol. 11 (2). – P. 117–119.
Inhibition of receptor activator of NF-kappaB ligand by denosumab attenuates vascular calcium deposition in mice / S. Helas, C. Goettsch, M. Schoppet [et al.] // Am. J. Pathol. – 2009. – Aug. – Vol. 175 (2). – P. 473–478.
Взаимосвязь минеральной плотности костей, липидного обмена и эндотелиальной функции у женщин с ИБС и постменопаузальным остеопорозом / И. С. Карпова, Н. А. Манак, О. В. Кошлатая // Боль. Суставы. Позвоночник. – 2012. – № 4 (08). – Режим доступа к журн. :
http://www.mif-ua.com/archive/article/34605.].
Rubin M. R. Vascular calcification and osteoporosis – the nature of the nexus / M. R. Rubin, S. J. Silverberg // J. Clin. Endocrinol. Metab. – 2004. – Sep. – Vol. 89 (9). – P. 4243–4245.
Aortic calcification and the risk of osteoporosis and fractures / E. Schulz, K. Arfai, X. Liu [et al.] // J. Clin. Endocrinol. Metab. – 2004. – Sep. – Vol. 89 (9). – P. 246–253.
Woo Shin Kim. Calcium-phosphorus product concentration is a risk factor of coronary artery disease in metabolic syndrome / Woo Shin Kim, Dong-Hyun Lee, Ho-Joong Youn // Atherosclerosis. – 2013. – July. – Vol. 229 (1). – P. 253–257.
Covic A. Vascular calcification in chronic kidney disease / A. Covic, M. Kanbay, L. Voroneanu // Clin. Sci. (Lond.). – 2010. – Vol. 119 (3). – P. 111–121.
Is obesity in women protective against osteoporosis? / S. Migliaccio, E. A. Greco, R. Fornari, L. M Donini // Diabetes Metab. Syndr. Obes. – 2011. – Vol. 4. – P. 273–282.
Взаимосвязь основных показателей кальциевого и липидного обмена с атеросклерозом коронарных артерий / Я. В. Полонская, E. В. Карташова, И. С. Мурашев [и др.] // Атеросклероз и дислипидемии. – 2015. – № 1. – С. 24–29.
Montalcini T. Serum calcium level is related to both intima-media thickness and carotid atherosclerosis a neglect risk factor in obese/overweight subject / T. Montalcini, G. Gorgone, A. Pujia // Journal of Translational Medicine. – 2012. – June 6. – Vol. 10. – P. 11. – DOI: 10.1186/1479-5876-10-114.
Altered calcium homeostasis is correlated with the presence of metabolic syndrome and diabetes in middle-aged and elderly Korean subjects / The Chungju Metabolic Disease Cohort study (CMC study) / Mee Kyoung Kim, Guilsun Kim, Eun Hee Jang [et al.] // Atherosclerosis. – 2010. – Vol. 212 (2). – P. 674–681. – DOI: 10.1016/j.atherosclerosis.2010.07.005.
Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis // L. J. Zhao, H. Jiang, C. J. Papasian [et al.] // J. Bone Miner Res. – 2008. – Vol. 23. – P. 17–29.