Keywords
thymus
histology
xenobiotics
polyethers
How to Cite
Abstract
Rapid technology growth and its implementation in all spheres of the people’s lives dictates the necessity for thorough study of the influence of different chemicals on human's health. This study was devoted to elucidation of MGMT activity in the thymus and spleen tissues under the influence of xenobiotics: tryglycidyl ether of polyoxypropylenetriol (TEPPT) and propylene glycol (PG). In subacute experiment were uncovered alterations of the matured male rat’s spleen and thymus after the administration of 1/10 LD50 and 1/100 LD50 of TEPPT and PG. The changes of morphologiс data are determined in comparison to control data which shows reactivity of the spleen and thymus in response to the induced xenobiotic. The effect of TEPPT and PG on the tissue of the spleen and thymus is expressed in the suppression of MGMT activity also; the inhibitory effect of TEPPT is more pronounced.
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