Morphological features of parathyroide glands of white rats after immunostimulation
Vol 75 No 2 (2017), Theoretical and Experimental Medicine
Vol 75 No 2 (2017)

Morphological features of parathyroide glands of white rats after immunostimulation

Theoretical and Experimental Medicine
Published February 10, 2020
V. Erokhina
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Keywords

parathyroid gland
rats
morphometry
immunostimulation
immunostimulant

How to Cite

Erokhina, V. (2020). Morphological features of parathyroide glands of white rats after immunostimulation. Medicine Today and Tomorrow, 75(2), 4–10. Retrieved from https://msz.knmu.edu.ua/article/view/355
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Abstract

The features of the morphometric parameters of the parathyroid glands of white rats were studied after the use of the derivative of the thymic hormone arginyl-asparagill-lysyl-valile-tyrosyl-arginine (AALVTA). The study was carried out on 48 male rats of reproductive age with an initial body weight (180±10) g. Animals were injected by immunostimulant on 50 mg/kg for the 1st, 3rd, 5th, 7th, 9th days. Intact rats served as control. The animals were brought out the experiment on the 3rd, 15th, 30th and 90th day after the completion of the injection. The linear parameters of the parathyroid glands (thickness, width, height), the area of the organ in the sections, the number of blood vessels in the field of vision of the slide and their diameter were estimated, the thickness of the capsular gland was measured. It was found that after the introduction of AALVTA there is a significant increase in the morphometric parameters of the glandular glands on 7, 15 and 30 days after the immune stimulation, which may indicate a high morphoreactivity of the organ. On 90th days the data are closer to the control values, which may indicate the compensatory and adaptive nature of the reaction in response to exogenous factor.

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References

Влияние паратиреоидэктомии на показатели костного метаболизма у пациентов с вторичным гиперпаратиреозом на фоне хронической болезни почек А. В. Величко, Ю. И. Ярец, С. Л. Зыблев [и др.] // Общая и частная хирургия. – 2016. – № 1. – С. 32–39.

Conigrave A. D. The calcium-sensing receptor and the parathyroid: past, present, future / A. D. Conigrave // Frontiers in Physiology. – 2016. – № 7, article 563.

Effects of parathyroid hormone on immune function / A. S. Geara, M. R. Castellanos, C. Bassil [et al.] // Clinical and Developmental Immunology. – 2010. Vol. 10, № 6. – P. 1–10.

Gaillard R. C. Conversation galante: How the immune and the neuroendocrine systems talk to each other / R. C. Gaillard // Autoimmunity Reviews. – 2007. – Vol. 7, № 1. – P. 23–29.

Chen H. Nerve fibres in the parathyroid gland of the Golden Hamster (Mesocricetus auratus): Immunohistochemical and ultrastructural investigations / H. Chen, S. Shoumura, S. Emura // Anatomia, histologia, embryologia. – 2005. – № 34. – P. 34–37.

Ланин Д. В. Нейроэндокринные механизмы регуляции функций иммунной системы / Д. В. Ланин, Н. В. Зайцева, О. В. Долгих // Успехи современной биологии. – 2011. – Т. 131, № 2. – С. 122–134.

Болгова Е. С. Динамика морфометрических показателей щитовидной железы половозрелых крыс под влиянием тимогена / Е. С. Болгова // Український медичний альманах. – 2004. – Т. 7, № 1. – С. 34–37.

Овчаренко В. В. Органометричні показники надниркових залоз щурів при тимектомії та застосуванні препарату тимогену / В. В. Овчаренко // Український медичний альманах. – 2004. – № 1. – С. 120–122.

Бобрышева И. В. Особенности структурно-функциональных изменений ацидофильных эндокриноцитов аденогипофиза крыс после применения имунофана / И. В. Бобрышева // Світ біології та медицини. – 2013. – № 1. – С. 100–104.

Морфофункциональное состояние структур тимуса, надпочечников и периферической крови через неделю после спленэктомии / Л. М. Меркулова, Г. Ю. Стручко, И. С. Стоменская, Т. В. Агафонкин // Вестник Чувашского университета. – 2001. – № 4. – С. 95–104.