Keywords
cortisol
intensive care
cognitive disorders
How to Cite
Abstract
The study included 105 patients with acute myocardial infraction in three groups: 34–40; 41–50 and 51–60 years old. The state of cognitive functions were studied using neuropsychological methods: MMSE, clock drawing test, test «memorizing 10 words» by A.R. Luria. There are 3 treatment regimens: the first treatment regimen – by quercetin; the second – by quercetin + 2ethyl-6-methyl-3-hydroxypyrimidine succinate; the third – quercetin + morpholinium – 3-methyl-1,2,4-triazolin-5-thiocetam. It is established a significant increase of cortisol blood serum level in all age groups of patients. The concentration of cortisol was highest in patients 34–40 years, which indicates a much more severe course of acute myocardial infarction. Patients receiving treatment with morpholinium-3-methyl-1,2,4-triazolin-5-tiocetam showed a decrease in cortisol concentrations already at the 3rd day of treatment. Reducing the cortisol concentration in blood serum in patients suffering from acute myocardial infarction confirms the indicators of neuropsychological tests and indicates a recurrence of cognitive impairment. When morpholinium-3-methyl-1,2,4-triazoline-5-tiocetam was added to standard therapy, there was a significant decrease in serum cortisol levels and cognitive impairment in patients with acute myocardial infarction under the age of 60 years. We confirmed that the definition of cortisol, as the main marker of stress, is promising and requires further study.
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