Abstract
In press
Esophageal cancer is an extremely serious and highly relevant issue with substantial medical and social significance. The significance is primarily due to its aggressive nature, as esophageal cancer progresses rapidly and is often diagnosed in its late stages. Late detection limits treatment options and generally leads to poorer survival outcomes, making it one of the most challenging cancers to manage. A study of data from the National Cancer Registry of Ukraine examined trends in standardized morbidity and mortality rates from 2016 to 2021. Over this period, the standardized morbidity rate decreased by 16.3%, while the standardized mortality rate dropped by 15.6%, suggesting some improvements in early detection and treatment approaches during those years. However, the outbreak of hostilities in Ukraine in 2022 created substantial barriers to healthcare operations, particularly in cancer centers. According to official data, military actions disrupted data collection, making it impossible to calculate standardized morbidity and mortality rates per capita for years 2022–2023. By the end of 2023, only data on the total number of patients registered in cancer care institutions were available. This lack of comprehensive data limits understanding of current trends in esophageal cancer and complicates planning for healthcare resources in the coming years. Wartime conditions pose unique challenges, as access to quality medical care may be restricted or delayed. For conditions like esophageal cancer, where early detection is crucial, limited access can lead to a higher likelihood of advanced-stage diagnoses, ultimately impacting prognosis and survival rates. These circumstances underscore the importance of maintaining continuity in cancer care, even under adverse conditions, through targeted healthcare planning.
Keywords: analysis of dynamics, cancer, mortality and morbidity.
References
Cavallin F, Scarpa M, Cagol M, Alfieri R, Ruol A, Chiarion Sileni V, et al. Time to diagnosis in esophageal cancer: a cohort study. Acta Oncol. 2018;57(9):1179-84. DOI: 10.1080/0284186X.2018.1457224. PMID: 29600882.
Global Cancer Observatory. [Internet]. Available at: https://gco.iarc.fr/en [accessed 20 Sep 2024].
Kirkilevskyi SI, Krakhmalov PS, Kondratskyi YuM, Frydel RI. Survival of patients with esophageal cancer depending on the localization of the primary tumor. Clinical Oncology. 2020;10(1-2(37-38)):7p. DOI: 10.32471/clinicaloncology.2663-466X.37-1.27028. [In Ukrainian].
Korolenko HS, Soloviova NYe, Shcherbynina MB. Esophageal cancer: a modern view of the problem. Oncology. Hematology. Chemotherapy. 2021;69(2):26-7. Available at: https://health-ua.com/article/65375-rak-stravohodu-suchasnij-poglyad-naproblemu [in Ukrainian].
Clinical manifestations, diagnosis, and staging of esophageal cancer, 31 May 2023. [Internet]. Available at: https://www.uptodate.com/contents/clinical-manifestations-diagnosis-and-staging-of-esophageal-cancer [accessed 20 Sep 2024].
The National Cancer Registry of Ukraine (NCRU). [Internet]. Available at: http://www.ncru.inf.ua/ [accessed 20 Sep 2024]. [In Ukrainian].
Fedorenko ZP, Hulak LO, Mykhailovych YuY, Horokh YeL, Ryzhov AYu, Sumkina OV, Kutsenko LB. Cancer in Ukraine, 2016–2017. Incidence, mortality, performance indicators of the oncology service. Bulletin of the National Cancer Registry of Ukraine 19. Kyiv: National Cancer Institute; 2018. 138 p. Available at: http://www.ncru.inf.ua/publications/BULL_19/index.htm [in Ukrainian].
Fedorenko ZP, Hulak LO, Mykhailovych YuY, Horokh YeL, Ryzhov AYu, Sumkina OV, Kutsenko LB. Cancer in Ukraine, 2018–2019. Incidence, mortality, performance indicators of the oncology service. Bulletin of the National Cancer Registry of Ukraine 21. Kyiv: National Cancer Institute; 2020. 147 p. Available at: http://ncru.inf.ua/publications/BULL_21/index.htm [in Ukrainian].
Fedorenko ZP, Hulak LO, Mykhailovych YuY, Horokh YeL, Ryzhov AYu, Sumkina OV, Kutsenko LB. Cancer in Ukraine, 2019–2020. Incidence, mortality, performance indicators of the oncology service. Bulletin of the National Cancer Registry of Ukraine 22. Kyiv: National Cancer Institute; 2021. 136 p. Available at: http://www.ncru.inf.ua/publications/BULL_22/index.htm [in Ukrainian].
Fedorenko ZP, Hulak LO, Mykhailovych YuY, Horokh YeL, Ryzhov AYu, Sumkina OV, Kutsenko LB. Cancer in Ukraine, 2021–2022. Incidence, mortality, performance indicators of the oncology service. Bulletin of the National Cancer Registry of Ukraine 24. Kyiv: National Cancer Institute; 2023. 148 p. Available at: http://www.ncru.inf.ua/publications/BULL_24/index.htm [in Ukrainian].
Fedorenko ZP, Hulak LO, Mykhailovych YuY, Horokh YeL, Ryzhov AYu, Sumkina OV, Kutsenko LB. Cancer in Ukraine, 2022–2023. Incidence, mortality, performance indicators of the oncology service. Bulletin of the National Cancer Registry of Ukraine 25. Kyiv: National Cancer Institute; 2024. 132 p. Available at: http://www.ncru.inf.ua/publications/BULL_25/index.htm [in Ukrainian].
Kovalov OO. War and cancer. Oncology. Hematology. Chemotherapy. 2022;1-2(74-75):4-5. Available at: https://bit.ly/3AtBBhz [in Ukrainian].
Kovalov KO, Kovalov OO. How the consequences of the war can affect the incidence of cancer in Ukraine and the European Union. Oncology. Hematology. Chemotherapy. 2022;78(5):22-3. Available at: https://health-ua.com/article/71485-yak-nasldki-vjni-mozhut-vplivati-nazahvoryuvanst-narak-vukran-takranah-vros [in Ukrainian].
What impact does war have on Ukrainian cancer care? King’s College (London), 29 Apr 2022. [Internet]. Available at: https://www.kcl.ac.uk/what-impact-does-war-have-on-ukrainian-cancer-care [accessed 20 Sep 2024].
Esophageal Cancer Treatment. US National Cancer Institute at the National Institutes of Health. Last update 15 Oct 2024. [Internet]. Available at: https://bit.ly/4e9p8gU [accessed 20 Sep 2024].
Dumanskyi YuV, Chekhun VF. Oncology in Ukraine: the state of the problem and ways of development. Oncology. 2022;24(3):1-6. DOI: 10.32471/oncology.2663-7928.t-24-3-2022-g.10652. [In Ukrainian].
Domper Arnal MJ, Ferrandez Arenas A, Lanas Arbeloa A. Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries. World Journal of Gastroenterology. 2015;21(26):7933-43. DOI: 10.3748/wjg.v21.i26.7933. PMID: 26185366.
Ajani JA, D’Amico TA, Almhanna K, Chao J, Corvera C, Das P, et al. Esophageal and esophagogastric junction cancers, Version 2.2019. Journal of the National Comprehensive Cancer Network. 2019;13(2):194-227. DOI: 10.6004/jnccn.2019.0033. PMID: 31319389.
Lawler M, Davies L, Oberst S, Oliver K, Eggermont A, Schmutz A, et al. European Groundshot-addressing Europe cancer research challenges: Lancet Oncology Commission. The Lancet. 2022;23:1133-44. DOI: 10.1016/S1470-2045(22)00540-X. PMID: 36400101.
Ferlay J, Colombet M, Soerjomataram I, Dyba T, Randi G, Bettio M, et al. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018. European journal of cancer. 2018;103:356-87. DOI: 10.1016/j.ejca.2018.07.005. PMID: 30100160.
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