Comparison of the effectiveness of treatment of temporomandibular joint osteoarthritis between monotherapy with splints and splints in combination with platelet-rich plasma
PDF (Українська)

Keywords

degenerative diseases
radiological density
articular head

How to Cite

Shynchukovskyi, I., & Tereshchuk, O. (2024). Comparison of the effectiveness of treatment of temporomandibular joint osteoarthritis between monotherapy with splints and splints in combination with platelet-rich plasma. Medicine Today and Tomorrow, 93(1). https://doi.org/10.35339/msz.2024.93.1.sht

Abstract

In press

Today there is a tendency to increase the prevalence of Temporomandibular Joint Osteoarthritis (TMJ) osteoarthritis, which is a chronic degenerative joint disease. According to international statistics, 28–38% of people in the age group of 9–90 years have signs of TMJ osteoarthritis. The aim of our study was to compare the effectiveness of treatment of TMJ osteoarthritis between monotherapy with splints and splinys in combination with Platelet-Rich Plasma (PRP). The experiment involved 8 patients, divided into 2 level groups. The control group (4 patients) received treatment with splints, the experimental group – splits with PRP therapy. The effectiveness of treatment was assessed by measuring the radiological density of the cortical plate of the mandibular head according to the Hounsfield scale, the degree of mouth opening, filling out a Visual Analogue Scale (VAS) and a questionnaire at the end of treatment. According to the results of the study, the experimental group received more effective treatment, which is confirmed by the VAS, the degree of mouth opening and changes in the radiological density of the cortical plate of the articular head. At the end of the treatment, patients completed a questionnaire about the improvement of their condition, where 0 points meant no effect from the treatment, and 10 points meant a subjective feeling of complete recovery. The arithmetic mean of the improvement scores in the control group was 6.75, and in the experimental group – 9.00 points. Based on the results of the experiment, we can state that the effectiveness of treatment of TMJ osteoarthritis with splints in combination with PRP therapy is greater than that of monotherapy with occlusal splints. Therefore, if the patient has no contraindications to treatment with platelet-rich plasma, we can recommend the use of splits in combination with PRP therapy for the treatment of temporomandibular joint osteoarthritis.

Keywords: degenerative diseases, radiological density, articular head.

https://doi.org/10.35339/msz.2024.93.1.sht
PDF (Українська)

References

Breedveld FC. Osteoarthritis – the impact of a serious disease. Rheumatology (Oxford). 2004;43_Suppl_1:i4-8. DOI: 10.1093/rheumatology/keh102. PMID: 14752169.

Singh J, Bhardwaj B. Treatment of Temporomandibular Joint Arthritis with Triamcinolone Acetonide and Hyaluronic Acid Injection: An Observational Study. Indian J Otolaryngol Head Neck Surg. 2020;72(4):403-10. DOI: 10.1007/s12070-019-01738-3. PMID: 33088766.

Juan Z, Xing-Tong M, Xu Z, Chang-Yi L. Potential pathological and molecular mechanisms of temporomandibular joint osteoarthritis. J Dent Sci. 2023;18(3):959-71. DOI: 10.1016/j.jds.2023.04.002. PMID: 37404608.

Yuce E, Komerik N. Comparison of the Efficiacy of Intra-Articular Injection of Liquid Platelet-Rich Fibrin and Hyaluronic Acid After in Conjunction With Arthrocentesis for the Treatment of Internal Temporomandibular Joint Derangements. J Craniofac Surg. 2020;31(7):1870-4. DOI: 10.1097/SCS.0000000000006545. PMID: 32433129.

Al-Hamed FS, Hijazi A, Gao Q, Badran Z, Tamimi F. Platelet Concentrate Treatments for Temporomandibular Disorders: A Systematic Review and Meta-analysis. JDR Clin Trans Res. 2021;6(2):174-83. DOI: 10.1177/2380084420927326. PMID: 32464073.

Wu CB, Sun NN, Zhang D, Wang Q, Zhou Q. Efficacy analysis of splint combined with platelet-rich plasma in the treatment of temporomandibular joint osteoarthritis. Front Pharmacol. 2022;13:996668. DOI: 10.3389/fphar.2022.996668. PMID: 36467093.

Farshidfar N, Jafarpour D, Firoozi P, Sahmeddini S, Hamedani S, de Souza RF, Tayebi L. The application of injectable platelet-rich fibrin in regenerative dentistry: A systematic scoping review of in vitro and in vivo studies. Jpn Dent Sci Rev. 2022;58:89-123. DOI: 10.1016/j.jdsr.2022.02.003. PMID: 35368368.

Misch CE. Bone density: A key determinant for clinical success. In: Misch CE, editor. Contemporary Implant Dentistry, 2nd ed. St Louis: CV Mosby Company; 1999. p. 109-18.

Everts P, Onishi K, Jayaram P, Lana JF, Mautner K. Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020. Int J Mol Sci. 2020;21(20):7794. DOI: 10.3390/ijms21207794. PMID: 33096812.

Glyn-Jones S, Palmer AJ, Agricola R, Price AJ, Vincent TL, Weinans H, Carr AJ. Osteoarthritis. Lancet. 2015;386(9991):376-387. DOI: 10.1016/S0140-6736(14)60802-3. PMID: 25748615.

Cartron AM, Shaikh G. Platelet-Rich Plasma: Cure-All at What Cost? Dermatol Surg. 2021;47(2):323. DOI: 10.1097/DSS.0000000000002357. PMID: 32141932.

Dhillon MS, Patel S, Bansal T. Improvising PRP for use in osteoarthritis knee- upcoming trends and futuristic view [published correction appears in J Clin Orthop Trauma. 2020;11(6):1175]. J Clin Orthop Trauma. 2019;10(1):32-5. DOI: 10.1016/j.jcot.2018.10.005.

Bhatia R, Chopra G. Efficacy of Platelet Rich Plasma via Lumbar Epidural Route in Chronic Prolapsed Intervertebral Disc Patients-A Pilot Study. J Clin Diagn Res. 2016;10(9):UC05-7. DOI: 10.7860/JCDR/2016/21863.8482. PMID: 27790553.

Khatab S, van Buul GM, Kops N, Bastiaansen-Jenniskens YM, Bos PK, Verhaar JA, van Osch GJ. Intra-articular Injections of Platelet-Rich Plasma Releasate Reduce Pain and Synovial Inflammation in a Mouse Model of Osteoarthritis. Am J Sports Med. 2018;46(4):977-86. DOI: 10.1177/0363546517750635. PMID: 29373806.

Wang K, Li J, Li Z, Wang B, Qin Y, Zhang N, et al. Chondrogenic Progenitor Cells Exhibit Superiority Over Mesenchymal Stem Cells and Chondrocytes in Platelet-Rich Plasma Scaffold-Based Cartilage Regeneration [published correction appears in Am J Sports Med. 2020;48(2):NP30]. Am J Sports Med. 2019;47(9):2200-15. DOI: 10.1177/0363546519854219. PMID: 31194571.

Xiong Y, Gong C, Peng X, Liu X, Su X, Tao X, et al. Efficacy and safety of platelet-rich plasma injections for the treatment of osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Front Med (Lausanne). 2023; 10:1204144. DOI: 10.3389/fmed.2023.1204144. PMID: 37441691.

Setiawan IGNY, Suyasa IK, Astawa P, Dusak IWS, Kawiyana IKS, Aryana IGNW. Recombinant platelet derived growth factor-BB and hyaluronic acid effect in rat osteoarthritis models. J Orthop. 2019;16(3):230-3. DOI: 10.1016/j.jor.2019.02.028. PMID: 30906129.

Xie X, Wang Y, Zhao C, Guo S, Liu S, Jia W, et al. Comparative evaluation of MSCs from bone marrow and adipose tissue seeded in PRP-derived scaffold for cartilage regeneration. Biomaterials. 2012;33(29):7008-18. DOI: 10.1016/j.biomaterials.2012.06.058. PMID: 22818985.

Manafikhi M, Ataya J, Heshmeh O. Evaluation of the efficacy of platelet rich fibrin (I-PRF) intra-articular injections in the management of internal derangements of temporomandibular joints – a controlled preliminary prospective clinical study. BMC Musculoskelet Disord. 2022;23(1):454. DOI: 10.1186/s12891-022-05421-7. PMID: 35568935.

Pietruszka P, Chruscicka I, Dus-Ilnicka I, Paradowska-Stolarz A. PRP and PRF-Subgroups and Divisions When Used in Dentistry. J Pers Med. 2021;11(10):944. DOI: 10.3390/jpm11100944. PMID: 34683085.

Liu SS, Xu LL, Fan S, Lu SJ, Jin L, Liu LK, et al. Effect of platelet-rich plasma injection combined with individualised comprehensive physical therapy on temporomandibular joint osteoarthritis: A prospective cohort study. J Oral Rehabil. 2022;49(2):150-9. DOI: 10.1111/joor.13261. PMID: 34562321.

Comert Kilic S, Gungormus M, Sumbullu MA. Is Arthrocentesis Plus Platelet-Rich Plasma Superior to Arthrocentesis Alone in the Treatment of Temporomandibular Joint Osteoarthritis? A Randomized Clinical Trial. J Oral Maxillofac Surg. 2015;73(8):1473-83. DOI: 10.1016/j.joms.2015.02.026. PMID: 25976690.

Lin SL, Tsai CC, Wu SL, Ko SY, Chiang WF, Yang JW. Effect of arthrocentesis plus platelet-rich plasma and platelet-rich plasma alone in the treatment of temporomandibular joint osteoarthritis: A retrospective matched cohort study (A STROBE-compliant article). Medicine (Baltimore). 2018;97(16):e0477. DOI: 10.1097/MD.0000000000010477. PMID: 29668626.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.